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首页 > 报刊文摘 > [Mechanisms Of Signal Transduction] S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-{alpha} Signaling through IKK2

[Mechanisms Of Signal Transduction] S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-{alpha} Signaling through IKK2

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S6K1 (p70S6K) is a serine kinase downstream from Akt in the insulin signaling pathway that is involved in negative feedback regulation of insulin action. S6K1 is also activated by TNF-, a pro-inflammatory cytokine. However, its role remains to be characterized.



出版机构:ASBMB刊物名称:Journal of Biological Chemistry
出版时间:2008
ISSN:0021-9258
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