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? The overall number of lumbar motoneurons does not decrease with age. ? No preferential loss of motoneurons based on size occurs with age. ? Old motoneurons die via apoptosis in a caspase-dependent manner. ? Caloric restriction down-regulates Hsp27, OGG1 and cytochrome c in old motoneurons. 出版机构：Elsevier Science 刊物名称：Mechanisms of Ageing and Development 出版时间：2010 ISSN：0047-6374 数据源：报刊文摘
Old age is associated with an enhanced susceptibility to stroke and poor recovery from brain injury, but the cellular processes underlying these phenomena are only partly understood. 出版机构：Elsevier Science 刊物名称：Ageing Research Reviews 出版时间：2011 ISSN：1568-1637 数据源：报刊文摘
One of the most common complaints among aging individuals is difficulty in understanding speech in a compromised listening environment, such as when background noise is present. 出版机构：Elsevier Science 刊物名称：Brain Research 出版时间：2010 ISSN：0006-8993 数据源：报刊文摘
Lifespan extension is significantly reduced in yca1 mutants as well in rho 0 strains, suggesting that the protective effects pass through the Yca1 caspase and mitochondrial functions. 出版机构：Blackwell Publishing Ltd 刊物名称：Aging Cell 出版时间：2010 ISSN：1474-9718 数据源：报刊文摘
Drosophila mitochondria contain two peroxidases, peroxiredoxin 3 (dPrx3) and peroxiredoxin 5 (dPrx5), which together constitute the sole known intramitochondrial mechanism for the catalytic removal of hydrogen and organic peroxides. 出版机构：Elsevier Science 刊物名称：Free Radical Biology and Medicine 出版时间：2010 ISSN：0891-5849 数据源：报刊文摘
The harlequin (hq)/Big Blue? mouse is a model of premature aging with neurodegeneration and a transgenic mutation target (?cII gene) for in vivo mutation analysis in individual tissues. 出版机构：Elsevier Science 刊物名称：Mutation Research 出版时间：2011 ISSN：0027-5107 数据源：报刊文摘
Background aims. Adipose-derived stem cells (ASC) are known to be able to restore injured tissue via differentiation and paracrine effects. In this study, we investigated the effect of ASC on photo-aged human dermal fibroblasts (HDF) based on paracrine function. 出版机构：Informa Healthcare 刊物名称：Cytotherapy 出版时间：2011 ISSN：1465-3249 数据源：报刊文摘
Oxidative stress, cellular damage, and neuronal apoptosis are believed to underlie the progressive cognitive decline that accompanies natural aging and to be exacerbated in neurodegenerative diseases.
出版机构：Springer Verlag 刊物名称：Neurotoxicity Research 出版时间：2011 ISSN：1029-8428 数据源：报刊文摘
For the first time, p53 was found in complex with the viral large T-antigen in cells transformed with the small DNA virus SV40. p53 cDNA was cloned in the early 1980s, and the full-length p53 gene was cloned soon afterwards. The p53 family is comprised of three genes?
出版机构：SP MAIK Nauka/Interperiodica 刊物名称：Molecular Biology 出版时间：2011 ISSN：0026-8933 数据源：报刊文摘
Immunohistochemical analysis of the expression of proapoptotic protein P53 and proliferation protein Ki-67 in human pineal gland showed that in people over 60 years pinealocyte proliferation is virtually absent. 出版机构：Springer US 刊物名称：Bulletin of Experimental Biology and Medicine 出版时间：2011 ISSN：0007-4888 数据源：报刊文摘
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