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In September 2009, the French Society of Genetic Toxicology and the German Society for Research on DNA Repair jointly organized the `2nd German-French DNA repair meeting ? DNA damage and repair in ageing and degenerative diseases?, which was held in Konstanz, Germany. 出版机构:Elsevier Science 刊物名称:Mechanisms of Ageing and Development 出版时间:2010 ISSN:0047-6374 数据源:报刊文摘
Inappropriate activation of a single enzyme, telomerase, is associated with the uncontrollable proliferation of cells observed in as many as 90% of all of human cancers. 出版机构:Future Medicine Ltd 刊物名称:Future Oncol. 出版时间:2009 ISSN:1479-6694 数据源:报刊文摘
ging is associated with increased incidence and prevalence of both cancer and anemia. Cancer and aging may conspire in making anemia more frequent and more severe. This article reviews the causes and the consequences of anemia in the older individual. 出版机构:Elsevier Science 刊物名称:Transfusion Clinique et Biologique 出版时间:2010 ISSN:1246-7820 数据源:报刊文摘
Helicases use the energy of ATP hydrolysis to separate double-stranded nucleic acids to facilitate essential processes such as replication, recombination, transcription and repair. This article focuses on the human RECQ helicase gene and protein family. 出版机构:Elsevier Science 刊物名称:Seminars in Cancer Biology 出版时间:2010 ISSN:1044-579X 数据源:报刊文摘
The data presented demonstrates a correlation of plasma cortisol levels and receptor sensitivity with mammalian longevity and replicative senescence; observations possibly related to the influence of cortisol on chaperone expression and cancer resistance.
出版机构:Springer Netherlands 刊物名称:Biogerontology 出版时间:2010 ISSN:1389-5729 数据源:报刊文摘
Cells of the gastrointestinal (GI) mucosa are subject to a constant process of renewal which, in normal adults, reflects a balance between the rates of cell production and cell loss. 出版机构:Bentham Science Publishers 刊物名称:Current Protein and Peptide Science 出版时间:2010 ISSN:1389-2037 数据源:报刊文摘
This review addresses the effects of age and inflammation on cancer development and progression, and speculates as to whether the modulation of inflammation may influence the response to cancer immunization. 出版机构:Springer Netherlands 刊物名称:Biogerontology 出版时间:2010 ISSN:1389-5729 数据源:报刊文摘
Mitochondrial DNA (mtDNA) mutations increase with age. However, the number of cells with predominantly mutated mtDNA is small in old animals. Here a new hypothesis is proposed: mtDNA fragments may insert into nuclear DNA contributing to aging and related diseases by alterations in the nucleus. 出版机构:Elsevier Science 刊物名称:Mitochondrion 出版时间:2010 ISSN:1567-7249 数据源:报刊文摘
There is growing scientific agreement that antioxidants, particularly the polyphenolic forms, may help lower the incidence of disease, such as certain cancers, cardiovascular and neurodegenerative diseases, DNA damage, or even have anti-aging properties. 出版机构:Bentham Science Publishers 刊物名称:CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS and Neurological Disorders) 出版时间:2011 ISSN:1871-5273 数据源:报刊文摘
Drug users with HIV infection successfully treated with highly active antiretroviral therapy are now living to older ages. As persons with HIV infection age, they become at risk for comorbidities that occur in any group of aging individuals. 出版机构:Informa Healthcare 刊物名称:Subst Use Misuse 出版时间:2011 ISSN:1082-6084 数据源:报刊文摘
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