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Cardiac Oxidative Stress and Inflammation are Similar in SAMP8 and SAMR1 Mice and Unaltered by Curcumin and Ginkgo biloba Extract Intake

Chronic inflammation and oxidative stress increase with advancing age and appear to be involved in the pathogenesis of coronary heart disease, the leading cause of death worldwide.

出版机构:Bentham Science Publishers

刊物名称:Current Pharmaceutical Biotechnology

出版时间:2010

ISSN:1389-2010

数据源:报刊文摘

Secretoglobin 3A2/uteroglobin-related protein 1 is a novel marker for pulmonary carcinoma in mice and humans

Secretoglobin (SCGB) 3A2, also called uteroglobin-related protein (UGRP) 1, is a downstream target for a homeodomain transcription factor NKX2-1, which is critical for the development of lung, thyroid and ventral forebrain.

出版机构:Elsevier Science

刊物名称:Lung Cancer

出版时间:2011

ISSN:0169-5002

数据源:报刊文摘

Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells

Here we determine the Fibroblast Growth Factor-2 (FGF2) dependency of the time course of changes in bone mass in female mice. This study extends our earlier reports that knockout of the FGF2 gene (Fgf2) caused low turnover bone loss in Fgf2 ? / ? male mice by examining bone loss with age in Fgf2 ?/?

出版机构:Elsevier Science

刊物名称:Bone

出版时间:2010

ISSN:8756-3282

数据源:报刊文摘

Mitochondrial DNA deletions in mice in men: Substantia nigra is much less affected in the mouse

Mitochondrial DNA (mtDNA) deletions have been reported to accumulate to high levels in substantia nigra of older humans, and these mutations are suspected of causing age-related degeneration in this area.

出版机构:Elsevier Science

刊物名称:Biochimica et Biophysica Acta (BBA)/Bioenergetics

出版时间:2010

ISSN:0005-2728

数据源:报刊文摘

Effects of brain‐derived neurotrophic factor on dopaminergic function and motor behavior during aging

Bdnf+/? and WT mice had similar body weights until 12 months of age; however, at 21 months, Bdnf+/? mice were significantly heavier than WT mice.

出版机构:Blackwell Publishing Ltd

刊物名称:Genes, Brain & Behavior

出版时间:2011

ISSN:1601-1848

数据源:报刊文摘

Model of radiation-accelerated aging and its specific features

We conducted a lifetime study of the content of oxidized and methylated guanine in the urine of intact and irradiated mice. For statistical processing of the results, we used the trial period method created by A.A. Konradov, which was unpublished during the author?s lifetime.

出版机构:SP MAIK Nauka/Interperiodica

刊物名称:Biophysics

出版时间:2010

ISSN:0006-3509

数据源:报刊文摘

Pharmacological modulation of contextual “episodic-like” memory in aged mice

In a second part, we described the effects of aging on memory in the contextual and serial discrimination (CSD) task. We showed more specifically that the CSD task allowed detection of early memory impairments in middle-aged (14?15 months) animals as compared to young (4?

出版机构:Elsevier Science

刊物名称:Behavioural Brain Research

出版时间:2010

ISSN:0166-4328

数据源:报刊文摘

An electron microscopic radioautographic study on the DNA synthesis of pulmonary tissue cells in aging mice

A peak in the labeling indices (LI) of the type 1 cells was found on the third day after birth, while that of the type 2, interstitial and endothelial cells was found on fetal day 16. Then they gradually decreased with age.

出版机构:Springer Verlag

刊物名称:Medical Electron Microscopy

出版时间:1995

ISSN:0918-4287

数据源:报刊文摘

Selective attention, working memory, and animal intelligence

umulating evidence indicates that the storage and processing capabilities of the human working memory system co-vary with individuals? performance on a wide range of cognitive tasks.

出版机构:Elsevier Science

刊物名称:Neuroscience & Biobehavioral Reviews

出版时间:2010

ISSN:0149-7634

数据源:报刊文摘

Limited expansion of virus-specific CD8 T cells in the aged environment

The mechanisms responsible for the diminished immune response seen with aging are unclear. In this study, we investigate the contributions of alterations in the lymphoid microenvironment to this decrease.

出版机构:Elsevier Science

刊物名称:Mechanisms of Ageing and Development

出版时间:2009

ISSN:0047-6374

数据源:报刊文摘