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A LINE-1 component to human aging: Do LINE elements exact a longevity cost for evolutionary advantage?

dvancing age remains the largest risk factor for devastating diseases, such as heart disease, stroke, and cancer. The mechanisms by which advancing age predisposes to disease are now beginning to unfold, due in part, to genetic and environmental manipulations of longevity in lower organisms.

出版机构:Elsevier Science

刊物名称:Mechanisms of Ageing and Development

出版时间:2010

ISSN:0047-6374

数据源:报刊文摘

2nd German-French DNA repair meeting – DNA damage and repair in ageing and degenerative diseases, Konstanz, Germany, September 20–23, 2009

In September 2009, the French Society of Genetic Toxicology and the German Society for Research on DNA Repair jointly organized the `2nd German-French DNA repair meeting ? DNA damage and repair in ageing and degenerative diseases?, which was held in Konstanz, Germany.

出版机构:Elsevier Science

刊物名称:Mechanisms of Ageing and Development

出版时间:2010

ISSN:0047-6374

数据源:报刊文摘

Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs?

The daily variation of these complex processes is due to changes in specific mechanisms. In the last years we focused on the influence of melatonin on the expression and function of nicotinic acetylcholine receptors (nAChRs). Melatonin, either ?in vivo? or ?in vitro?

出版机构:Elsevier Science

刊物名称:Pharmacology & Therapeutics

出版时间:2010

ISSN:0163-7258

数据源:报刊文摘

Ketogenic diets: An historical antiepileptic therapy with promising potentialities for the aging brain

Ketogenic diets (KDs), successfully used in the therapy of paediatric epilepsy for nearly a century, have recently shown beneficial effects also in cancer, obesity, diabetes, GLUT 1 deficiencies, hypoxia-ischemia, traumatic brain injuries, and neurodegeneration.

出版机构:Elsevier Science

刊物名称:Ageing Research Reviews

出版时间:2010

ISSN:1568-1637

数据源:报刊文摘

Acute exercise reverses aged-induced impairments in insulin signaling in rodent skeletal muscle

Aging rats were subjected to swimming for two 1.5-h long bouts, separated by a 45min rest period. Sixteen hours after the exercise, the rats were killed and proteins from the insulin signaling pathway were analyzed by immunoblotting.

出版机构:Elsevier Science

刊物名称:Mechanisms of Ageing and Development

出版时间:2010

ISSN:0047-6374

数据源:报刊文摘

Genetic influences on cognitive functions in the elderly: A selective review of twin studies

In this review, we examined the published reports on the heritability of cognitive functioning in old age. Twenty-four papers from five study centers, comprising of participants with a mean age of 65years and above were examined.

出版机构:Elsevier Science

刊物名称:Brain Research Reviews

出版时间:2010

ISSN:0165-0173

数据源:报刊文摘

Reduction of Basal Forebrain Cholinergic System Parallels Cognitive Impairment in Patients at High Risk of Developing Alzheimer's Disease

Neuropathological studies suggest that the basal forebrain cholinergic system (BFCS) is affected in Alzheimer's disease (AD), but there is no in vivo evidence of early damage to this system in subjects at high risk of developing AD.

出版机构:Oxford University Press

刊物名称:Cerebral Cortex

出版时间:2010

ISSN:1047-3211

数据源:报刊文摘

Predictors of nutrition information comprehension in adulthood

The goal of the present study was to examine relationships among several predictors of nutrition comprehension. We were particularly interested in exploring whether nutrition knowledge or motivation moderated the effects of attention on comprehension across a wide age range of adults.

出版机构:Elsevier Science

刊物名称:Patient Education and Counseling

出版时间:2010

ISSN:0738-3991

数据源:报刊文摘

Mitochondrial DNA repair and association with aging – An update

Mitochondrial DNA is constantly exposed to oxidative injury. Due to its location close to the main site of reactive oxygen species, the inner mitochondrial membrane, mtDNA is more susceptible than nuclear DNA to oxidative damage.

出版机构:Elsevier Science

刊物名称:Experimental Gerontology

出版时间:2010

ISSN:0531-5565

数据源:报刊文摘

Different expression of α and β mitochondrial estrogen receptors in the aging rat brain: Interaction with respiratory complex V

Recent evidence suggests that hormonal effects on mitochondria could be mediated by mitochondrial estrogen receptors (mtERs). These receptors are new candidates for the beneficial estrogenic effects on mitochondria in different physiological conditions.

出版机构:Elsevier Science

刊物名称:Experimental Gerontology

出版时间:2010

ISSN:0531-5565

数据源:报刊文摘