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dvancing age remains the largest risk factor for devastating diseases, such as heart disease, stroke, and cancer. The mechanisms by which advancing age predisposes to disease are now beginning to unfold, due in part, to genetic and environmental manipulations of longevity in lower organisms. 出版机构：Elsevier Science 刊物名称：Mechanisms of Ageing and Development 出版时间：2010 ISSN：0047-6374 数据源：报刊文摘
In September 2009, the French Society of Genetic Toxicology and the German Society for Research on DNA Repair jointly organized the `2nd German-French DNA repair meeting ? DNA damage and repair in ageing and degenerative diseases?, which was held in Konstanz, Germany. 出版机构：Elsevier Science 刊物名称：Mechanisms of Ageing and Development 出版时间：2010 ISSN：0047-6374 数据源：报刊文摘
The daily variation of these complex processes is due to changes in specific mechanisms. In the last years we focused on the influence of melatonin on the expression and function of nicotinic acetylcholine receptors (nAChRs). Melatonin, either ?in vivo? or ?in vitro? 出版机构：Elsevier Science 刊物名称：Pharmacology & Therapeutics 出版时间：2010 ISSN：0163-7258 数据源：报刊文摘
Ketogenic diets (KDs), successfully used in the therapy of paediatric epilepsy for nearly a century, have recently shown beneficial effects also in cancer, obesity, diabetes, GLUT 1 deficiencies, hypoxia-ischemia, traumatic brain injuries, and neurodegeneration. 出版机构：Elsevier Science 刊物名称：Ageing Research Reviews 出版时间：2010 ISSN：1568-1637 数据源：报刊文摘
Aging rats were subjected to swimming for two 1.5-h long bouts, separated by a 45min rest period. Sixteen hours after the exercise, the rats were killed and proteins from the insulin signaling pathway were analyzed by immunoblotting. 出版机构：Elsevier Science 刊物名称：Mechanisms of Ageing and Development 出版时间：2010 ISSN：0047-6374 数据源：报刊文摘
In this review, we examined the published reports on the heritability of cognitive functioning in old age. Twenty-four papers from five study centers, comprising of participants with a mean age of 65years and above were examined. 出版机构：Elsevier Science 刊物名称：Brain Research Reviews 出版时间：2010 ISSN：0165-0173 数据源：报刊文摘
Neuropathological studies suggest that the basal forebrain cholinergic system (BFCS) is affected in Alzheimer's disease (AD), but there is no in vivo evidence of early damage to this system in subjects at high risk of developing AD. 出版机构：Oxford University Press 刊物名称：Cerebral Cortex 出版时间：2010 ISSN：1047-3211 数据源：报刊文摘
The goal of the present study was to examine relationships among several predictors of nutrition comprehension. We were particularly interested in exploring whether nutrition knowledge or motivation moderated the effects of attention on comprehension across a wide age range of adults. 出版机构：Elsevier Science 刊物名称：Patient Education and Counseling 出版时间：2010 ISSN：0738-3991 数据源：报刊文摘
Mitochondrial DNA is constantly exposed to oxidative injury. Due to its location close to the main site of reactive oxygen species, the inner mitochondrial membrane, mtDNA is more susceptible than nuclear DNA to oxidative damage. 出版机构：Elsevier Science 刊物名称：Experimental Gerontology 出版时间：2010 ISSN：0531-5565 数据源：报刊文摘
Recent evidence suggests that hormonal effects on mitochondria could be mediated by mitochondrial estrogen receptors (mtERs). These receptors are new candidates for the beneficial estrogenic effects on mitochondria in different physiological conditions. 出版机构：Elsevier Science 刊物名称：Experimental Gerontology 出版时间：2010 ISSN：0531-5565 数据源：报刊文摘
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