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Hydrogen-Rich Saline Protects Against Spinal Cord Injury in Rats

In the present study, we examined the mechanisms of hydrogen-rich saline, a reported therapeutic antioxidant, in the treatment of acute spinal cord contusion injury. Male Sprague-Dawley rats were used to produce a standardized model of contuses spinal cord injury (125 kdyn force).

出版机构:Springer US

刊物名称:Neurochemical Research

出版时间:2010

ISSN:0364-3190

数据源:报刊文摘

Early identification of the risk for free radical-related diseases in preterm newborns

Despite recent advances in preterm newborns healthcare, perinatal pathologies and disabilities are increasing.

出版机构:Elsevier Science

刊物名称:Early Human Development

出版时间:2010

ISSN:0378-3782

数据源:报刊文摘

Generation of active bactericidal forms of oxygen by leukocytes circulating through the lungs

Without Abstract

出版机构:Springer US

刊物名称:Bulletin of Experimental Biology and Medicine

出版时间:1989

ISSN:0007-4888

数据源:报刊文摘

Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis

The synthetic retinoid N-(4-hydroxyphenyl)retinamide (4HPR) exhibits anticancer activity in vivo and triggers apoptosis in transformed cells in vitro. Thus, apoptosis induction is acknowledged as a mechanistic underpinning for 4HPR's cancer preventive and therapeutic effects.

出版机构:Elsevier Science

刊物名称:Free Radical Biology and Medicine

出版时间:2010

ISSN:0891-5849

数据源:报刊文摘

Enhanced superoxide and hydrogen peroxide detection in biological assays

Superoxide reductase (SOR) is an enzyme that converts superoxide into hydrogen peroxide at a twofold higher yield than canonical superoxide dismutases (SOD).

出版机构:Elsevier Science

刊物名称:Free Radical Biology and Medicine

出版时间:2010

ISSN:0891-5849

数据源:报刊文摘

A novel profluorescent nitroxide as a sensitive probe for the cellular redox environment

Changes to the redox status of biological systems have been implicated in the pathogenesis of a wide variety of disorders. Sensitive quantification of these changes has been developed using a novel fluorescent probe containing a redox-sensitive nitroxide moiety.

出版机构:Elsevier Science

刊物名称:Free Radical Biology and Medicine

出版时间:2010

ISSN:0891-5849

数据源:报刊文摘

A radiation-induced adaptive response prolongs the survival of prion-infected mice

Previously, it has been demonstrated that an "adaptive response" that includes the prevention, repair, and removal of oxidative damage can be evoked by radiation at dose rates substantially lower than those at which risks have been observed.

出版机构:Elsevier Science

刊物名称:Free Radical Biology and Medicine

出版时间:2010

ISSN:0891-5849

数据源:报刊文摘

Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice

major pathway for chronic ethanol-induced liver injury is ethanol-induced oxidant stress. Several pathways contribute to mechanisms by which ethanol induces oxidant stress. Although some studies support a role for cytochrome P450 2E1 (CYP2E1), others do not.

出版机构:Elsevier Science

刊物名称:Free Radical Biology and Medicine

出版时间:2010

ISSN:0891-5849

数据源:报刊文摘

Role of oxidative stress in high-glucose- and diabetes-induced increased expression of Gq/11α proteins and associated signaling in vascular smooth muscle cells

We have recently shown that aortic vascular smooth muscle cells (VSMCs) from streptozotocin (STZ)-induced diabetic rats and A10 VSMCs exposed to high glucose exhibited increased levels of Gq? and PLC? proteins.

出版机构:Elsevier Science

刊物名称:Free Radical Biology and Medicine

出版时间:2010

ISSN:0891-5849

数据源:报刊文摘

Hydrogen peroxide mediates EGCG-induced antioxidant protection in human keratinocytes

The beneficial health effects of (?)-epigallocatechin-3-gallate (EGCG), the main catechin of green tea, have been attributed to complex interactions with a focus on antioxidative properties.

出版机构:Elsevier Science

刊物名称:Free Radical Biology and Medicine

出版时间:2010

ISSN:0891-5849

数据源:报刊文摘