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Effect of pfkA chromosomal interruption on growth, sporulation, and production of organic acids in Bacillus subtilis

Phosphofructokinase (Pfk) plays a key role in the regulation of carbohydrate metabolism. Its activity can be used as an indicator of glycolytic flux in a microorganism. We have cloned and characterized the pfkA gene from Bacillus subtilis, which encodes the enzyme phosphofructokinase.

出版机构:WILEY‐VCH Verlag

刊物名称:Journal of Basic Microbiology

出版时间:2010

ISSN:0233-111X

数据源:报刊文摘

Investigation of piceid metabolites in rat by liquid chromatography tandem mass spectrometry

There is considerable evidence that stilbenes provide health benefits. Trans-piceid is one of the major stilbenoid compounds in red wine and other plants.

出版机构:Elsevier Science

刊物名称:Journal of Chromatography B, Analytical Technologies in the Biomedical and

出版时间:2011

ISSN:1570-0232

数据源:报刊文摘

In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB2) in rat liver microsomes

The in vitro metabolism of an inverse agonist of the peripheral cannabinoid receptor (CB2), indomethacin morpholinylamide (BML-190), has been characterized using rat liver microsomal incubation. BML-190 was found to yield at least 15 metabolic products as identified by HPLC?MS/MS analysis.

出版机构:Elsevier Science

刊物名称:European Journal of Pharmaceutical Sciences

出版时间:2010

ISSN:0928-0987

数据源:报刊文摘

Diclofenac metabolic profile followingin vitro percutaneous absorption through viable human skin

Summary The extent of metabolism of diclofenac sodium in excised viable human skin was investigated using combination HPLC and radioactivity assay.

出版机构:Springer Verlag

刊物名称:European Journal of Drug Metabolism and Pharmacokinetics

出版时间:1999

ISSN:0378-7966

数据源:报刊文摘

Acetaminophen presystemic biotransformation vs bioavailability in therapeutical dosage range

Summary The influence of dose on the absorption and presystemic biotransformation of acetaminophen was studied in 15 healthy volunteers after administration of 3 different oral doses (250 mg, 500 mg, 750 mg) following a 3?3 Latin Square Design.

出版机构:Springer Verlag

刊物名称:European Journal of Drug Metabolism and Pharmacokinetics

出版时间:1998

ISSN:0378-7966

数据源:报刊文摘

In vivo metabolism of 2-[1′-phenyl-3′-(3-chlorophenyl)-2′-propenylyden]hydraz ino-3-methyl-4(3H)-quinazolinone in rats

Summary The aim of this study was to investigate by HPLC the in vivo metabolism of 2-[1?-phenyl-3?-(3-chlorophenyl)-2?-propenylyden]hydrazino-3-methyl-4(3H)-quinazolinone as a substrate, and as a model compound in rats.

出版机构:Springer Verlag

刊物名称:European Journal of Drug Metabolism and Pharmacokinetics

出版时间:2005

ISSN:0378-7966

数据源:报刊文摘

High pressure liquid chromatographic analysis ofin vivo metabolites ofN(substituted phenyl)-N′-(1,3,5-trimethyl pyrazole-4-yl)thioureas in rats

Summary The aim of this study was to investigate the in vivo metabolism ofN-(substituted phenyl)-N-( 1,3,5-trimethylpyrazole-4-yl)thioureas (substrate) as model compounds in rats via HPLC.

出版机构:Springer Verlag

刊物名称:European Journal of Drug Metabolism and Pharmacokinetics

出版时间:2007

ISSN:0378-7966

数据源:报刊文摘

Molecular-biological problems of drug design and mechanism of drug action

Major metabolites of the new original peptide (neurotensin analog) dilept (N-caproyl-L-prolyl-L-tyrosine methyl ester), which was designed at the Zakusov Institute of Pharmacology, were isolated and identified using an HPLC?MS/MS method.

出版机构:Springer US

刊物名称:Pharmaceutical Chemistry Journal

出版时间:2010

ISSN:0091-150X

数据源:报刊文摘

The In Silico Prediction of Human-Specific Metabolites from Hepatotoxic Drugs

In this study we employed the use of the Meteor computational software program to perform predictions in silico on 17 hepatotoxic drugs for determining human-specific drug metabolites.

出版机构:Bentham Science Publishers

刊物名称:Current Drug Discovery Technologies

出版时间:2010

ISSN:1570-1638

数据源:报刊文摘

Quantitative metabolism using AMS: Choosing a labeled precursor

Biological radioisotope studies suffer from a lack of sensitive measurement techniques and therefore traditionally require large amounts of labeled material to produce a measurable signal.

出版机构:Elsevier Science

刊物名称:Nuclear Instruments and Methods in Physics Research Section B: Beam

出版时间:2010

ISSN:0168-583X

数据源:报刊文摘