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HPLC method with fluorescence detection for the quantitative determination of flaxseed lignans

We report a rapid and simple HPLC method with fluorescence detection for the quantification of the major flaxseed lignan, secoisolarisiresinol diglucoside (SDG) and its major metabolites. The method is specific for SDG, secoisolarisiresinol (SECO), enterodiol (ED) and entrolactone (EL) in rat serum.

出版机构:Elsevier Science

刊物名称:Journal of Chromatography B, Analytical Technologies in the Biomedical and

出版时间:2010

ISSN:1570-0232

数据源:报刊文摘

Pharmacokinetics of a novel nifedipine and pH-sensitive N-succinyl chitosan/alginate hydrogel bead in rabbits

Context: A novel N-succinyl chitosan/alginate hydrogel bead was prepared by the ionic gelation method for controlled delivery of nifedipine (NF). Objective: The delivery behavior of NF from the hydrogel bead was studied in rabbit body.

出版机构:Informa Healthcare

刊物名称:Drug Dev Ind Pharm

出版时间:2010

ISSN:0363-9045

数据源:报刊文摘

Clearance of vancomycin during continuous infusion in Intensive Care Unit patients: correlation with measured and estimated creatinine clearance and serum cystatin C

Vancomycin (VAN) dosing requires adjustment to renal function, which is often estimated using the Cockcroft?Gault formula; however, its precision is poor in Intensive Care Unit (ICU) patients.

出版机构:Elsevier Science

刊物名称:International Journal of Antimicrobial Agents

出版时间:2010

ISSN:0924-8579

数据源:报刊文摘

Preparation of penta-O-galloyl-β-d-glucose from tannic acid and plasma pharmacokinetic analyses by liquid–liquid extraction and reverse-phase HPLC

The gallotannin penta-O-galloyl-beta-d-glucose (PGG) has many biological activities including in vivo anti-cancer efficacy. We present in this paper a scaled-up protocol for its preparation in high purity from tannic acid by acidic methanolysis with typical yield of 15%.

出版机构:Elsevier Science

刊物名称:Journal of Pharmaceutical and Biomedical Analysis

出版时间:2011

ISSN:0731-7085

数据源:报刊文摘

A HPLC-UV method for the determination of puerarin in rat plasma after intravenous administration of PEGylated puerarin conjugate

ensitive and reproducible HPLC method for quantitative determination of puerarin (PUE) in rat plasma was developed and validated using 4-hydroxybenzaldehyde as an internal standard. The separation of PUE was performed on a CAPCELL PAK C18 column by gradient elution with 0.

出版机构:Elsevier Science

刊物名称:Journal of Chromatography B, Analytical Technologies in the Biomedical and

出版时间:2010

ISSN:1570-0232

数据源:报刊文摘

High performance liquid chromatography assay with ultraviolet detection for moxifloxacin: Validation and application to a pharmacokinetic study in Chinese volunteers

pecific, sensitive and widely applicable high performance liquid chromatography with ultraviolet detection (HPLC-UV) method for the determination of moxifloxacin in human plasma was developed and validated in this study. The method involved a single step of liquid?

出版机构:Elsevier Science

刊物名称:Journal of Chromatography B, Analytical Technologies in the Biomedical and

出版时间:2010

ISSN:1570-0232

数据源:报刊文摘

Effects of food and gender on the pharmacokinetics of rhein and emodin in rats after oral dosing with Da‐Cheng‐Qi decoction

Da?Cheng?Qi decoction (DCQD), a traditional Chinese medicine preparation used to treat digestive diseases, is composed of dahuang (Rheum officinale Baill, Polygonaceae), houpu (Magnolia officinalis Rehd.

出版机构:John Wiley & Sons, Ltd.

刊物名称:Phytotherapy Research

出版时间:2011

ISSN:0951-418X

数据源:报刊文摘

An HPLC method for the pharmacokinetic study of daidzein-loaded nanoparticle formulations after injection to rats

This study was aimed at developing a simple HPLC method for the detection of daidzein in rat plasma. Daidzein was extracted from rat plasma with ethylparaben as internal standards (IS). Chromatographic separation of daidzein and IS was achieved by a Dikma Dimonsil C18 column (200mm?4.

出版机构:Elsevier Science

刊物名称:Journal of Chromatography B, Analytical Technologies in the Biomedical and

出版时间:2011

ISSN:1570-0232

数据源:报刊文摘

Method development for β-glucogallin and gallic acid analysis: Application to urinary pharmacokinetic studies

eversed phase high-pressure liquid chromatographic electrospray tandem mass spectrometry method was developed for the simultaneous detection and analysis of ?-glucogallin and gallic acid. This method used a C18 column with ultraviolet detection at 285nm, ionization in the negative ion mode for ?

出版机构:Elsevier Science

刊物名称:Journal of Pharmaceutical and Biomedical Analysis

出版时间:2011

ISSN:0731-7085

数据源:报刊文摘

High-performance liquid chromatography assay of gnetol in rat serum and application to pre-clinical pharmacokinetic studies

method of analysis of gnetol (2,3?,5?,6-tetrahydroxy-trans-stilbene) in biological fluids is necessary for the study of its kinetics and disposition in plants.

出版机构:Elsevier Science

刊物名称:Journal of Pharmaceutical and Biomedical Analysis

出版时间:2011

ISSN:0731-7085

数据源:报刊文摘