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Metabolism of Dynorphin A 1-13 in Human Blood and Plasma

AbstractPurpose. A detailed investigation of the metabolic routes and rates of Dyn A1-13 in human blood and plasma was performed.Methods. Human plasma was incubated at 37°C with dynorphin A 1-13 (Dyn Al-13, 15-20 µM).

出版机构:Springer US

刊物名称:Pharmaceutical Research

出版时间:1995

ISSN:0724-8741

数据源:报刊文摘

Estimation of Impurity Profiles of Drugs and Related Materials. 12. Isolation and Identification of an Isomeric Impurity in Danazol

AbstractWe report on a new isomeric impurity of danazol. This impurity designated as isodanazol was detected by reversed-phase high-performance liquid chromatography (HPLC) and thin-layer chromatography (TLC). Its structure was determined after separation by preparative HPLC.

出版机构:Springer US

刊物名称:Pharmaceutical Research

出版时间:1995

ISSN:0724-8741

数据源:报刊文摘

Accumulation of anthracenyl-amino acid topoisomerase I and II inhibitors in drug-sensitive and drug-resistant human ovarian cancer cell lines determined by high-performance liquid chromatography

The method uses an Apex ODS-2 column and a mobile phase of 0.25M ammonium acetate/trifluoroacetic acid (pH 3) in methanol with gradient elution. Selective detection is achieved by monitoring at 545 nm, with limits of detection ranging between 2 and 4 ng on the column.

出版机构:Springer Verlag

刊物名称:Cancer Chemotherapy and Pharmacology

出版时间:1995

ISSN:0344-5704

数据源:报刊文摘

D-L amino acid analysis using automated precolumn derivatization with 1-fluoro-2,4-dinitrophenyl-5-alanine amide

SummaryAn automated procedure for the precolumn derivatization of enantiomeric amino acid mixtures with 1-fluoro-2,4-dinitrophenyl-5-alanine amide and a liquid chromatographic method for the separation of the derivatives with UV detection are reported.

出版机构:Springer Vienna

刊物名称:Amino Acids

出版时间:1995

ISSN:0939-4451

数据源:报刊文摘

Retinal dopamine and lens-induced refractive errors in chicks

This study investigated the relationship between retinal dopamine and lens induced refractive errors in chicks by high performance liquid chromatography with ultraviolet detection (HPLC-UV) After two weeks of lens wear, the chick eyes treated with +10D lenses were hyperopic (+8.29 ? 0.

出版机构:Informa Healthcare

刊物名称:Current Eye Research

出版时间:1995

ISSN:0271-3683

数据源:报刊文摘

SYNTHESES WITH SULFUR CONTAINING NUCLEOPHILES. I. REACTION OF SULFINIC ACIDS WITH 2-HALOGENO-2-NITROETHENYLARENES

The interaction between unsubstituted and p-substituted benzenesulfinic acids and various 2-halogeno-2-nitroethenylarenes at mol ratios sulfinic acid:2-halogeno-2-nitroethenylarene = 1:1 and 2:1 was studied at 0?C and 20?C for 16 and 96 hours.

出版机构:Taylor & Francis

刊物名称:Phosphorus, Sulfur, and Silicon and the Related Elements

出版时间:1995

ISSN:1042-6507

数据源:报刊文摘

Separation of Imazalil and T824 in Cucurbits—Part one: Comparison of HPLC Reversed-Phase Columns

Seven reversed-phase columns, HRPB, Kromasil 100-5-C18, S5ODS2B, Vydac 218TP, YMC Polymer C18, Zorbax SBPhenyl and Zorbax SBCN, were compared with the polymeric Hamilton PRP-1 used so far, for ability to separate and determine imazalil and its degradation product, T824.

出版机构:Taylor & Francis

刊物名称:International Journal of Environmental & Analytical Chemistry

出版时间:1995

ISSN:0306-7319

数据源:报刊文摘

Mercury Speciation in Biological Samples

n extraction method is proposed in order to evaluate mercury species in biological samples (e.g. fish, mushrooms). Sulphur-containing ligands have been considered and thiourea was chosen for the optimised extraction procedure according to the best recovery obtained (65.9%, 75.8%, 47.1% and 98.

出版机构:Taylor & Francis

刊物名称:International Journal of Environmental & Analytical Chemistry

出版时间:1995

ISSN:0306-7319

数据源:报刊文摘

In Vivo Voltammetry and Microdialysis Monitoring of Monoamine Metabolism in the Rat Brainstem Neurons

Two ?in vivo? techniques allow the monitoring of extracellular levels of monoamines and related compounds in selected rat brainstem regions : voltammetry and microdialysis. ?In vivo?

出版机构:Informa Healthcare

刊物名称:Clin Exp Hypertens

出版时间:1995

ISSN:1064-1963

数据源:报刊文摘

Analysis of bromofenoxim by supercritical fluid chromatography and comparison with an HPLC method

Bromofenoxim is a herbicide widely used in several European countries: surprisingly, there is a lack of suitable analytical methods to measure it in water.

出版机构:Taylor & Francis

刊物名称:Toxicological and Environmental Chemistry

出版时间:1995

ISSN:0277-2248

数据源:报刊文摘