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High pressure liquid chromatographic analysis ofin vivo metabolites ofN(substituted phenyl)-N′-(1,3,5-trimethyl pyrazole-4-yl)thioureas in rats

Summary The aim of this study was to investigate the in vivo metabolism ofN-(substituted phenyl)-N-( 1,3,5-trimethylpyrazole-4-yl)thioureas (substrate) as model compounds in rats via HPLC.

出版机构:Springer Verlag

刊物名称:European Journal of Drug Metabolism and Pharmacokinetics

出版时间:2007

ISSN:0378-7966

数据源:报刊文摘

An improved HPLC method for determination of nifuratel in human plasma and its application to pharmacokinetics studies

Summary A rapid, simple and sensitive high-performance liquid chromatography (HPLC) method was established for the quantification of nifuratel in human plasma and applied to a study of its pharmacokinetics.

出版机构:Springer Verlag

刊物名称:European Journal of Drug Metabolism and Pharmacokinetics

出版时间:2007

ISSN:0378-7966

数据源:报刊文摘

Biochemical characterisation of two forms of halo- and thermo-tolerant chitinase C ofSalinivibrio costicola expressed inEscherichia coli

Chi-II was derived from Chi-I by C-terminal processing. Chi-I and Chi-II showed similar salinity optimum at 1?2% NaCl and retained more than 80% of their activity at 3?5% NaCl and more than 50% residual activity at 14% NaCl.

出版机构:Springer Verlag

刊物名称:Annals of Microbiology

出版时间:2007

ISSN:1590-4261

数据源:报刊文摘

Proteomics, pigment composition, and organization of thylakoid membranes in iron-deficient spinach leaves

The changes induced in the photosynthetic apparatus of spinach (Spinacia oleracea L.) seedlings exposed to iron deficiency shortly after germination were characterized with two proteomic approaches coupled with chlorophyll and xanthophyll analysis and in vivo measurements of photosynthesis.

出版机构:Oxford University Press

刊物名称:Journal of Experimental Botany

出版时间:2007

ISSN:0022-0957

数据源:报刊文摘

A Validated Stability Indicating High Performance Reverse Phase Liquid Chromatographic Method for the Determination of Cilostazol in Bulk Drug Substance

imple, rapid and accurate reverse phase high-performance liquid chromatographic (RP-HPLC) method was developed for the quantitative determination of cilostazol. The developed method is also applicable for the related substance determination in bulk drugs.

出版机构:Informa Healthcare

刊物名称:Drug Dev Ind Pharm

出版时间:2007

ISSN:0363-9045

数据源:报刊文摘

Determination of Clozapine and its Metabolite, Norclozapine in Various Biological Matrices Using High-Performance Liquid Chromatography

Purpose. To develop and validate an HPLC method for the quantitation of clozapine and its metabolite, norclozapine in human plasma, rat plasma, and the various human plasma lipoprotein fractions. Methods.

出版机构:Informa Healthcare

刊物名称:Drug Dev Ind Pharm

出版时间:2007

ISSN:0363-9045

数据源:报刊文摘

HPLC Analysis for Simultaneous Determination of Rabeprazole and Domperidone in Pharmaceutical Formulation

imple and sensitive reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed for the quantitative estimation of rabeprazole and domperidone in their combined dosage forms. Rabeprazole and domperidone were chromatographed using 0.01 M, pH 6.

出版机构:Taylor & Francis

刊物名称:Journal of Liquid Chromatography & Related Technologies

出版时间:2007

ISSN:1082-6076

数据源:报刊文摘

Determination of a Selective GABA-A α2,3 Partial Agonist in Human Plasma by High Performance Liquid Chromatography with Tandem Mass Spectrometric Detection

n automated solid phase extraction, utilizing a 96-well plate format, was used to isolate a selective GABA-A ?2,3 partial agonist (I) and internal standard (II) from human plasma.

出版机构:Taylor & Francis

刊物名称:Journal of Liquid Chromatography & Related Technologies

出版时间:2007

ISSN:1082-6076

数据源:报刊文摘

Temperature—the Tool in Separation of Alkaloids by RP-HPLC

The retention behavior of 12 alkaloids on two different stationary phases, was based on silica matrix C18 and pentafluorophenyl by use of aqueous eluents consisting of acetonitrile, water, acetate buffer, and ion-pair reagent (OSA-Na) or silanol blocker (DEA).

出版机构:Taylor & Francis

刊物名称:Journal of Liquid Chromatography & Related Technologies

出版时间:2007

ISSN:1082-6076

数据源:报刊文摘

TLC Analysis of a Corrinoid Compound from Dark Muscle of the Yellowfin Tuna (Thunnus albacares)

ignificant amount of vitamin B12 (52.9?8.9 ?g/100 g) was found in the dark muscle of the yellowfin tuna (Thunnus albacares), in comparison to that of the light muscle. A corrinoid compound was purified to homogeneity from the dark muscle and partially characterized.

出版机构:Taylor & Francis

刊物名称:Journal of Liquid Chromatography & Related Technologies

出版时间:2007

ISSN:1082-6076

数据源:报刊文摘