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Expression of the Hippocampal NMDA Receptor GluN1 Subunit and Its Splicing Isoforms in Schizophrenia: Postmortem Study

There is accumulating evidence that disturbances in N-methyl-d-aspartate receptor (NMDA-R) functioning are associated with the pathogenesis of schizophrenia.

出版机构:Springer US

刊物名称:Neurochemical Research

出版时间:2010

ISSN:0364-3190

数据源:报刊文摘

Alcohol use and hippocampal volume deficits in adults with posttraumatic stress disorder: A meta-analysis

Posttraumatic stress disorder (PTSD) is associated with hippocampal volume deficits, but the effects of alcohol use on hippocampal volume in PTSD are unclear. We meta-analytically examined the relationship between alcohol use, PTSD, and hippocampal volume deficits.

出版机构:Elsevier Science

刊物名称:Biological Psychology

出版时间:2010

ISSN:0301-0511

数据源:报刊文摘

Genetic disruption of the autism spectrum disorder risk gene PLAUR induces GABAA receptor subunit changes

Disruption of the GABAergic system has been implicated in multiple developmental disorders, including epilepsy, autism spectrum disorder and schizophrenia. The human gene encoding uPAR (PLAUR) has been shown recently to be associated with the risk of autism.

出版机构:Elsevier Science

刊物名称:Neuroscience

出版时间:2010

ISSN:0306-4522

数据源:报刊文摘

Hippocampal expression and distribution of CB1 receptors in the Amazonian rodent Proechimys: An animal model of resistance to epilepsy

Proechimys, a rodent living in the Amazon region, has shown resistance to developing chronic epilepsy when submitted to different experimental models. Recently, many studies have attributed a potent anticonvulsant action to cannabinoid receptor CB1.

出版机构:Elsevier Science

刊物名称:Brain Research

出版时间:2010

ISSN:0006-8993

数据源:报刊文摘

Variants of contextual fear conditioning are differentially impaired in the juvenile rat by binge ethanol exposure on postnatal days 4–9

Neonatal ethanol exposure in the rat is known to partially damage the hippocampus, but such exposure causes only modest or inconsistent deficits on hippocampus-dependent behavioral tasks. This may reflect variable sensitivity of these tasks or residual function following partial hippocampal injury.

出版机构:Elsevier Science

刊物名称:Behavioural Brain Research

出版时间:2010

ISSN:0166-4328

数据源:报刊文摘

Amygdala and Hippocampus Enlargement During Adolescence in Autism

The amygdala and hippocampus are key components of the neural system mediating emotion perception and regulation and are thought to be involved in the pathophysiology of autism.

出版机构:Elsevier Science

刊物名称:Journal of the American Academy of Child & Adolescent Psychiatry

出版时间:2010

ISSN:0890-8567

数据源:报刊文摘

Stress impairs spatial but not early stimulus–response learning

Recent evidence indicates that stress modulates multiple memory systems, favoring caudate nucleus-based stimulus?response learning at the expense of hippocampus-based spatial learning. Whether this is due to a facilitating effect of stress on stimulus?

出版机构:Elsevier Science

刊物名称:Behavioural Brain Research

出版时间:2010

ISSN:0166-4328

数据源:报刊文摘

Effect of levetiracetam on hippocampal protein expression and cell proliferation in rats

Levetiracetam (LEV) is a broad-spectrum antiepileptic drug (AED) with possibly also antiepileptogenic properties. LEV has a specific binding site in the central nervous system and reduces brain excitability; however, the precise mechanism of action (MOA) of LEV remains unclear.

出版机构:Elsevier Science

刊物名称:Epilepsy Research

出版时间:2010

ISSN:0920-1211

数据源:报刊文摘

A high cholesterol diet elevates hippocampal cytokine expression in an age and estrogen-dependent manner in female rats

While the effects of a proatherogenic diet have been widely studied in the context of systemic inflammation, much less is known about its effects on central or brain inflammation and its modulation with age.

出版机构:Elsevier Science

刊物名称:Journal of Neuroimmunology

出版时间:2010

ISSN:0165-5728

数据源:报刊文摘

Conditioning-like Brief Neonatal Hypoxia Improves Cognitive Function and Brain Tissue Properties with Marked Gender Dimorphism in Adult Rats

lthough recent studies have documented compensatory generation of neurons in adult brains in response to various insults, a noninjurious short episode of hypoxia in rat neonates has been shown to trigger neurogenesis within the ensuing weeks, without apparent brain lesions.

出版机构:Elsevier Science

刊物名称:Seminars in Perinatology

出版时间:2010

ISSN:0146-0005

数据源:报刊文摘