Chromatographic methods for the quantification of free and chelated gadolinium species in MRI contrast agent formulations

Speciation measurements of gadolinium in liposomal MRI contrast agents (CAs) are complicated by the presence of emulsifiers, surfactants, and therapeutic agents in the formulations.

出版机构：Springer Verlag

刊物名称：Analytical and Bioanalytical Chemistry

出版时间：2010

ISSN：1618-2642

数据源：报刊文摘

Characterization and In Vitro and In Vivo Testing of CB2-Receptor- and NGAL-Targeted Paramagnetic Micelles for Molecular MRI of Vulnerable Atherosclerotic Plaque

Purpose Atherosclerotic plaque macrophages express the peripheral cannabinoid receptor (CB2-R) and promote fibrous cap degradation by secretion of neutrophil gelatinase-associated lipocalin 2 (NGAL).

出版机构：Springer Verlag

刊物名称：Molecular Imaging and Biology

出版时间：2010

ISSN：1536-1632

数据源：报刊文摘

Use of a reference tissue and blood vessel to measure the arterial input function in DCEMRI

Accurate measurement of the arterial input function is critical for quantitative evaluation of dynamic contrast enhanced magnetic resonance imaging data.

NMR relaxation and magnetic properties of superparamagnetic nanoworms

Maghemite particles are used as T₂ contrast agents for magnetic resonance imaging, especially for molecular and cellular imaging. Linear clusters of particles ? called nanoworms ? were recently developed to enhance the targeting efficiency.

Intracellular bimodal nanoparticles based on quantum dots for high-field MRI at 21.1 T

Multimodal, biocompatible contrast agents for high magnetic field applications represent a new class of nanomaterials with significant potential for tracking of fluorescence and MR in vitro and vivo. Optimized for high-field MR applications-including biomedical imaging at 21.

In vivo carotid plaque MRI using quantitative T2* measurements with ultrasmall superparamagnetic iron oxide particles: a dose–response study to statin therapy

This study investigates T₂* quantification in carotid plaques before and after the administration of ultrasmall superparamagnetic iron oxide particles (USPIOs) in a cohort of patients receiving statin therapy.

Chemical exchange saturation transfer (CEST): What is in a name and what isn't?

The focus of this review is on basic magnetic resonance principles underlying CEST and similarities to and differences with conventional magnetization transfer contrast. In CEST magnetic resonance imaging, transfer of magnetization is studied in mobile compounds instead of semisolids.

Rapid T1 mapping of mouse myocardium with saturation recovery look‐locker method

Dynamic contrast?enhanced MRI using gadolinium or manganese provides unique characterization of myocardium and its pathology. In this study, an electrocardiography (ECG) triggered saturation recovery Look?

In vivo detection of PARACEST agents with relaxation correction

Several pulse sequences have been used to detect paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents in animals to quantify the uptake over time following a bolus injection. The observed signal change is a combination of relaxation effects and PARACEST contrast.

Reconstruction and expression of the MRI-contrast protein, ferritin, with recombinant rabies vectors

Attenuated recombinant rabies vector could be an ideal system for delivery of contrast agent gene for Magnetic Resonance Imaging (MRI) because of its neurotropic nature.

出版机构：Springer Netherlands

刊物名称：Biotechnology Letters

出版时间：2010

ISSN：0141-5492

数据源：报刊文摘