Mouse myocardial first‐pass perfusion MR imaging

A first?pass myocardial perfusion sequence for mouse cardiac MRI is presented. A segmented ECG?triggered acquisition combined with parallel imaging acceleration was used to capture the first pass of a Gd?DTPA bolus through the mouse heart with a temporal resolution of 300?400 msec.

Motor deficits and neurofibromatosis type 1 (NF1)‐associated MRI impairments in a mouse model of NF1

Neurofibromatosis type 1 (NF1) is a genetic disorder characterized inter alia by cognitive and motor dysfunction and appearance of high?signal foci on T2?weighted images in the brain. Nf1^+/?

Detection of T2 changes in an early mouse brain tumor

The aim of the study was to determine the effect of early tumor growth on T2 relaxation times in an experimental glioma model. A 9.4-T magnetic resonance imaging (MRI) system was used for the investigations.

Validation of simple and robust protocols for high-resolution lung proton MRI in mice

One fundamental limitation of spatial resolution for in vivo MR lung imaging is related to motion in the thoracic cavity. To overcome this limitation, several methods have been proposed, including scan-synchronous ventilation and the cardiac gating approach.

A high‐throughput eight‐channel probe head for murine MRI at 9.4 T

Murine MRI studies are conducted on dedicated MR systems, typically equipped with ultra?high?field magnets (?4.7 T; bore size: ~12?25 cm), using a single transmit?receive coil (volume or surface coil in linear or quadrature mode) or a transmit?receive coil combination.

Functional evaluation of therapeutic response for a mouse model of medulloblastoma

Medulloblastoma is an aggressive childhood cerebellar tumor. We recently reported a mouse model with conditional deletion of Patched1 gene that recapitulates many characteristics of the human medulloblastoma.

出版机构：Springer Netherlands

刊物名称：Transgenic Research

出版时间：2010

ISSN：0962-8819

数据源：报刊文摘

Profiles with microscopic resolution by single-sided NMR

ingle-sided NMR sensor to produce depth profiles with microscopic spatial resolution is presented. It uses a novel permanent magnet geometry that generates a highly flat sensitive volume parallel to the scanner surface.

Evaluation of infarcted murine heart function: comparison of prospectively triggered with self‐gated MRI

Measurement of cardiac function is often performed in mice after, for example, a myocardial infarction. Cardiac MRI is often used because it is noninvasive and provides high temporal and spatial resolution for the left and right ventricle.

Magnetic resonance imaging follow-up of liver growth of neuroendocrine tumors in an experimental mouse model

Liver metastases in patients with gastroenteropancreatic (GEP) endocrine tumors represent the main factor of adverse prognosis in this tumor type and thus have a strong effect on the therapeutic strategies.

In vivo detection of PARACEST agents with relaxation correction

Several pulse sequences have been used to detect paramagnetic chemical exchange saturation transfer (PARACEST) contrast agents in animals to quantify the uptake over time following a bolus injection. The observed signal change is a combination of relaxation effects and PARACEST contrast.