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Challenges in the indirect quantitation of acyl-glucuronide metabolites of a cardiovascular drug from complex biological mixtures in the absence of reference standards

This paper describes the quantitation of acyl-glucuronide metabolites (M26 and M5) of a cardiovascular-drug (torcetrapib) from monkey urine, in the absence of their reference standards.

出版机构:John Wiley & Sons, Ltd.

刊物名称:Biomedical Chromatography

出版时间:2010

ISSN:0269-3879

数据源:报刊文摘

Organic Metabolites Produced by Vibrio Parahaemolyticus Strain An3 Isolated from Goan Mullet Inhibit Bacterial Fish Pathogens

Identification and action of several antibacterial metabolites produced by a fish pathogen Vibrio parahaemolyticus strain An3 from marine ecosystem of Goa has been demonstrated.

出版机构:Academic Journals

刊物名称:African Journal of Biotechnology

出版时间:2010

ISSN:1684-5315

数据源:报刊文摘

d-Isomer of gly-tyr-pro-cys-pro-his-pro peptide: A novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry

This paper describes a d-peptide isomer-based trapping assay using an LC/MS ion-trap spectrometer with an electrospray ionization (ESI) source as the analytical tool to study bioactivation of xenobiotics.

出版机构:Elsevier Science

刊物名称:Toxicology in Vitro

出版时间:2011

ISSN:0887-2333

数据源:报刊文摘

A systematic investigation to optimize simultaneous extraction and liquid chromatography tandem mass spectrometry analysis of estrogens and their conjugated metabolites in milk

In this study, the simultaneous extraction of estrone (E1), 17?-estradiol (E2), estriol (E3), ethinylestradiol (EE2), and their glucuronated and sulfated metabolites in milk was optimized using solid-phase extraction (SPE).

出版机构:Elsevier Science

刊物名称:Journal of Chromatography A

出版时间:2010

ISSN:0021-9673

数据源:报刊文摘

“Lossless” compression of high resolution mass spectra of small molecules

We demonstrate the utility of the filter for urinary metabolite profiling using direct infusion electrospray ionization and a 15 tesla FTICR mass spectrometer.

出版机构:Springer US

刊物名称:Metabolomics

出版时间:2010

ISSN:1573-3882

数据源:报刊文摘

LC and LC–MS Study of the Bioavailability and Metabolites of TM208 after Oral and Intravenous Administration to Rat

4-Methylpiperazine-1-carbodithioic acid 3-cyano-3,3-diphenylpropyl ester hydrochloride (TM208) is a new compound expected to become a new drug because of excellent in vivo and in vitro anticancer activity and low toxicity.

出版机构:Vieweg Verlag

刊物名称:Chromatographia

出版时间:2010

ISSN:0009-5893

数据源:报刊文摘

Testosterone metabolism revisited: discovery of new metabolites

The metabolism of testosterone is revisited. Four previously unreported metabolites were detected in urine after hydrolysis with KOH using a liquid chromatography tandem mass spectrometry method and precursor ion scan mode.

出版机构:Springer Verlag

刊物名称:Analytical and Bioanalytical Chemistry

出版时间:2010

ISSN:1618-2642

数据源:报刊文摘

Solid-phase extraction liquid chromatography–tandem mass spectrometry analytical method for the determination of 2-hydroxy-4-methoxybenzophenone and its metabolites in both human urine and semen

2-Hydroxy-4-methoxybenzophenone (HMB), which is one of the most commonly used UV filters in sunscreen cosmetics to protect skin from the deleterious effects of the sun, can be percutaneously absorbed, further metabolized, and finally excreted or bioaccumulated.

出版机构:Springer Verlag

刊物名称:Analytical and Bioanalytical Chemistry

出版时间:2010

ISSN:1618-2642

数据源:报刊文摘

Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether and their major metabolites dihydroartemisinin and dihydroartemisinin‐glucuronide in sheep plasma

Recently, promising fasciocidal activities of artesunate and artemether were described in rats and sheep. Therefore, a liquid chromatography?tandem mass spectrometry (LC?

出版机构:John Wiley & Sons, Ltd.

刊物名称:Journal of Mass Spectrometry

出版时间:2011

ISSN:1076-5174

数据源:报刊文摘

Quantification of dialkylphosphate metabolites of organophosphorus insecticides in human urine using 96-well plate sample preparation and high-performance liquid chromatography–electrospray ionization-tandem mass spectrometry

Organophosphorus (OP) pesticides kill by disrupting a targeted pest's brain and nervous systems. But if humans and other animals are sufficiently exposed, OP pesticides can have the same effect on them. We developed a fast and accurate high-performance liquid chromatography?

出版机构:Elsevier Science

刊物名称:Journal of Chromatography B, Analytical Technologies in the Biomedical and

出版时间:2010

ISSN:1570-0232

数据源:报刊文摘