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3β‐hydroxy‐Δ5‐C27‐steroid dehydrogenase/isomerase deficiency in a patient who underwent oral bile acid therapy for 10 years and delivered two healthy infants

出版机构:Blackwell Publishing Asia

刊物名称:Pediatrics International

出版时间:2010

ISSN:1328-8067

数据源:报刊文摘

The National Austrian Newborn Screening Program – Eight years experience with mass spectrometry. Past, present, and future goals

Summary BACKGROUND: The National Austrian Newborn Screening Program for inherited metabolic and endocrinologic disorders was introduced in 1966.

出版机构:Springer Verlag

刊物名称:Wiener klinische Wochenschrift

出版时间:2010

ISSN:0043-5325

数据源:报刊文摘

Central carbon metabolism of Leishmania parasites

SUMMARYLeishmania spp. are sandfly-transmitted protozoa parasites that cause a spectrum of diseases in humans. Many enzymes involved in Leishmania central carbon metabolism differ from their equivalents in the mammalian host and are potential drug targets.

出版机构:Cambridge University Press

刊物名称:Parasitology

出版时间:2010

ISSN:0031-1820

数据源:报刊文摘

Metabolic stability and determination of cytochrome P450 isoenzymes' contribution to the metabolism of medetomidine in dog liver microsomes

Medetomidine is a potent and selective �2-adrenergic agonist. The activation of �2-adrenergic receptor mediates a variety of effects including sedation, analgesia, relief of anxiety, vasoconstriction and bradycardia.

出版机构:John Wiley & Sons, Ltd.

刊物名称:Biomedical Chromatography

出版时间:2010

ISSN:0269-3879

数据源:报刊文摘

Liquid Chromatography-tandem Mass Spectrometry for Analysis of Acylcarnitines in Dried Blood Specimens Collected at Autopsy from Neonatal Intensive Care Unit

To investigate the feasibility of analyzing acylcarnitine in dry filter-paper blood spots by liquid chromatography-tandem mass spectrometry (LC-MS/MS) which could be applied to detect inborn errors of metabolism in neonates.

出版机构:Elsevier Science

刊物名称:Chinese Medical Sciences Journal

出版时间:2010

ISSN:1001-9294

数据源:报刊文摘

In vitro metabolism of indomethacin morpholinylamide (BML-190), an inverse agonist for the peripheral cannabinoid receptor (CB2) in rat liver microsomes

The in vitro metabolism of an inverse agonist of the peripheral cannabinoid receptor (CB2), indomethacin morpholinylamide (BML-190), has been characterized using rat liver microsomal incubation. BML-190 was found to yield at least 15 metabolic products as identified by HPLC?MS/MS analysis.

出版机构:Elsevier Science

刊物名称:European Journal of Pharmaceutical Sciences

出版时间:2010

ISSN:0928-0987

数据源:报刊文摘

Disposition of bazedoxifene in rats

Bazedoxifene acetate (BZA), a novel selective estrogen receptor modulator, is currently being developed for the prevention and treatment of osteoporosis in post-menopausal women. In this study, the disposition of BZA was determined in the rat, a pharmacology and safety model. After a single 0.2?

出版机构:Informa Healthcare

刊物名称:Xenobiotica

出版时间:2010

ISSN:0049-8254

数据源:报刊文摘

Isolation, identification and immunosuppressive activity of SDZ-IMM-125 metabolites from human liver microsomes

Summary SDZ-IMM-125 N-methyl leucine 9 hydroxylated in the ? position is a metabolite which was extracted from incubated human liver microsomes and subsequently separated by normal and reverse-phase HPLC.

出版机构:Springer Verlag

刊物名称:European Journal of Drug Metabolism and Pharmacokinetics

出版时间:1999

ISSN:0378-7966

数据源:报刊文摘

In vitro metabolism of GV150013X by using liver microsomes and liver tissue slices from different species

This compound was found to be converted to at least 8 metabolites by rat and human liver microsomes. In rabbit microsomes, the three metabolites M4, M7 and M8, and in dog liver microsomes metabolite M1, were not detected.

出版机构:Springer Verlag

刊物名称:European Journal of Drug Metabolism and Pharmacokinetics

出版时间:1997

ISSN:0378-7966

数据源:报刊文摘

A new approach to measuring estrogen exposure and metabolism in epidemiologic studies

Endogenous estrogen plays an integral role in the etiology of breast and endometrial cancer, and conceivably ovarian cancer. However, the underlying mechanisms and the importance of patterns of estrogen metabolism and specific estrogen metabolites have not been adequately explored.

出版机构:Elsevier Science

刊物名称:The Journal of Steroid Biochemistry and Molecular Biology

出版时间:2010

ISSN:0960-0760

数据源:报刊文摘