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Structure-activity relationship of marinostatin, a serine protease inhibitor isolated from a marine organism

12-residue MST isolated from a marine organism is a potent serine protease inhibitor that has a double cyclic structure composed of two ester linkages formed between the ?-hydroxyl and ?-carboxyl groups, Thr3-Asp9 and Ser8-Asp11.

出版机构:John Wiley & Sons, Ltd.

刊物名称:Journal of Peptide Science

出版时间:2010

ISSN:1075-2617

数据源:报刊文摘

Stability studies of oxazolidine-based compounds using 1H NMR spectroscopy

eries of oxazolidine-based compounds with a variety of substituents in positions 2 and 3 was synthesized and their stability studied. Ring opened intermediates formed on addition of limiting amounts of D2O to oxazolidine solutions, as observed by NMR.

出版机构:Wiley Subscription Services, Inc., A Wiley Company

刊物名称:Journal of Pharmaceutical Sciences

出版时间:2010

ISSN:0022-3549

数据源:报刊文摘

NMR solution structure and function of the C‐terminal domain of eukaryotic class 1 polypeptide chain release factor

Termination of translation in eukaryotes is triggered by two polypeptide chain release factors, eukaryotic class?1 polypeptide chain release factor (eRF1) and eukaryotic class?2 polypeptide chain release factor?3. eRF1 is a three?domain protein that interacts with eukaryotic class?

出版机构:Blackwell Publishing Ltd

刊物名称:FEBS Journal

出版时间:2010

ISSN:1742-464X

数据源:报刊文摘

Synthesis and structural properties of oligonucleotides covalently linked to acridine and quindoline derivatives through a threoninol linker

idine and quindoline derivatives linked to DNA stabilize duplex and quadruplex structuresOligonucleotide conjugates containing acridine and quindoline derivatives linked through a threoninol molecule were synthesized.

出版机构:Elsevier Science

刊物名称:Bioorganic & Medicinal Chemistry

出版时间:2010

ISSN:0968-0896

数据源:报刊文摘

Synthesis of 3-Substituted Isoxazolecarboxamides as Potential Fungicides

eries of new 3-substituted isoxazolecarboxamides have been prepared from aldehydes. A key step was a 1,3-dipolar cycloaddition of nitrile oxides to ?,?-unsaturated esters.

出版机构:Bentham Science Publishers

刊物名称:Letters in Organic Chemistry

出版时间:2010

ISSN:1570-1786

数据源:报刊文摘

Synthesis, structure and cytotoxic activity of new 1‐[5‐organylsilyl(germyl)‐2‐furyl (thienyl)]nitroethenes

New highly cytotoxic 1?[5?organylsilyl(germyl)?2?furyl(thienyl)]nitroethenes (IC500.3?3 ?g ml?1) have been prepared by condensation reaction of corresponding silicon? and germanium?

出版机构:John Wiley & Sons, Ltd.

刊物名称:Applied Organometallic Chemistry

出版时间:2010

ISSN:0268-2605

数据源:报刊文摘

Dimensionally and thermally stable polymer, containing disordered graphitic structure and adamantane

In an attempt to develop a low?k interlayer dielectric, adamantane?diphenyldiethynyl moiety containing oligomer is prepared. Oligomerization of 1,3,5,7?tetrakis[3/4?ethynylphenyl]adamantane (4) is accomplished by a Glaser?

出版机构:Wiley Subscription Services, Inc., A Wiley Company

刊物名称:Journal of Polymer Science Part A: Polymer Chemistry

出版时间:2006

ISSN:0887-624X

数据源:报刊文摘

High Resolution Magic Angle Spinning NMR Applied to the Analysis of Organic Compounds Bound to Solid Supports

In situ structural characterization of organic compounds attached to solid supports can be achieved by high-resolution magic angle spinning NMR (HRMAS NMR), a technique that provides solution-like spectra for resin-bound molecules.

出版机构:Bentham Science Publishers

刊物名称:Current Topics in Medicinal Chemistry

出版时间:2011

ISSN:1568-0266

数据源:报刊文摘

The Leiodolide B Puzzle

Out of options? Even though a systematic approach was chosen, which led to a set of four diastereomeric macrolides modeled around the proposed structure of leiodolide?B (see picture), the puzzle concerning the stereostructure of this cytotoxic metabolite derived from a deep?

出版机构:WILEY‐VCH Verlag

刊物名称:Angewandte Chemie International Edition

出版时间:2011

ISSN:1433-7851

数据源:报刊文摘

Asymmetric Phase Transfer Reactions Catalyzed by Chiral Crown Ethers Derived from Monosaccharides

One of the practical applications of sugar-based crown ethers involves their use as chiral catalysts in enantioselective phase transfer reactions.

出版机构:Bentham Science Publishers

刊物名称:Letters in Organic Chemistry

出版时间:2010

ISSN:1570-1786

数据源:报刊文摘