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We investigated the therapeutic effect of zonisamide against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice, using Western blot analysis, immunohistochemistry and behavioral test.
出版机构：Springer US 刊物名称：Metabolic Brain Disease 出版时间：2010 ISSN：0885-7490 数据源：报刊文摘
We examined the influence of several factors that can affect visual scanning, including oculomotor, basic visual, and cognitive abilities (executive function). 出版机构：Elsevier Science 刊物名称：Neuropsychologia 出版时间：2010 ISSN：0028-3932 数据源：报刊文摘
Our group previously described increased reactive oxygen species (ROS) production within easily accessible peripheral blood mononuclear cells (PBMCs) in PD patients compared to healthy elderly subjects. 出版机构：Elsevier Science 刊物名称：Neuroscience Letters 出版时间：2010 ISSN：0304-3940 数据源：报刊文摘
Ishibashi K, Kanemaru K, Saito Y, Murayama S, Oda K, Ishiwata K, Mizusawa H, Ishii K. Cerebrospinal fluid metabolite and nigrostriatal dopaminergic function in Parkinson's disease.
Acta Neurol Scand: 2010: 122: 46-51.
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出版机构：Blackwell Publishing Ltd 刊物名称：Acta Neurologica Scandinavica 出版时间：2010 ISSN：0001-6314 数据源：报刊文摘
Summary Deep brain stimulation (DBS) is an effective neurosurgical therapy for treatment of motor symptoms in Parkinson?s disease (PD). DBS of the subthalamic nucleus (STN-DBS) leads to a significant reduction of hypokinetic and hyperkinetic symptoms and improvement in quality of life.
出版机构：Springer Verlag 刊物名称：Der Nervenarzt 出版时间：2010 ISSN：0028-2804 数据源：报刊文摘
Summary Long-term care after deep brain stimulation for Parkinson?s disease requires regular technical check-ups as well as clinical follow-up. Residual or emerging difficulties with gait, balance or speech should be addressed by specific rehabilitation programs.
出版机构：Springer Verlag 刊物名称：Der Nervenarzt 出版时间：2010 ISSN：0028-2804 数据源：报刊文摘
The Staircase test measures lateralised deficits in skilled paw reaching in rodents, and there is a long-standing discrepancy in the literature on whether the paradigm is sensitive to graft-mediated functional recovery in the rodent model of Parkinson's disease. 出版机构：Elsevier Science 刊物名称：Behavioural Brain Research 出版时间：2010 ISSN：0166-4328 数据源：报刊文摘
Parkinson's disease (PD) is the second most common neurodegenerative disorder caused by selective degeneration of the dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). 出版机构：Elsevier Science 刊物名称：Neurochemistry International 出版时间：2010 ISSN：0197-0186 数据源：报刊文摘
To assess the influence of somatic symptoms of the Hamilton Depression Rating Scale (HAMD) and Montgomery??sberg Depression Rating Scale (MADRS) on the clinimetric performance of these scales in patients with Parkinson's disease (PD). 出版机构：Elsevier Science 刊物名称：Journal of Psychosomatic Research 出版时间：2010 ISSN：0022-3999 数据源：报刊文摘
Low-frequency (?1Hz) rTMS (LF-rTMS) can reduce excitability in the underlying cortex and/or promote inhibition. In patients with Parkinson?s disease (PD) several TMS elicited features of motor corticospinal physiology suggest presence of impaired inhibitory mechanisms. 出版机构：Elsevier Science 刊物名称：Clinical Neurophysiology 出版时间：2010 ISSN：1388-2457 数据源：报刊文摘
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