Molecular Modeling, Total Synthesis, and Biological Evaluations of C9-Deoxy Bryostatin 1 Financial support for this work was provided by the National Institutes of Health through grant GM28961, in part by the intramural research program of the NIH, NCI, CCR, and in part with federal funds from the National Cancer Institute, National Institutes of Health, under contract HHSN261200800001E.

No Abstract

Total Synthesis of Nominal Banyaside B: Structural Revision of the Glycosylation Site

The total synthesis of the tripeptide nominal banyaside?B relies on nonstandard peptide?bond?forming reactions. A key outcome of these synthetic studies is the proposal of a revised structure for natural banyaside?

Total Synthesis of Tryprostatins A and B

A reasonable approach to the radical: The establishment of reliable conditions for the radical?mediated construction of indoles enabled the highly efficient synthesis of tryprostatins?A and B. Use of the radical initiator 2,2??azobis(4?methoxy?2,4?

Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics

Proteasome inhibitors are rapidly evolving as potent treatment options in cancer therapy. One of the most promising drug candidates of this type is salinosporamide?A from the bacterium Salinispora tropica. This marine natural product possesses a complex, densely functionalized ??lactam???

Synthesis of Indole Derivatives with Biological Activity by Reactions Between Unsaturated Hydrocarbons and N-Aromatic Precursors

The present review is devoted to illustrate the state of the art of the syntheses of indoles, focusing particularly on the most recent developments of new synthetic approaches. Emphasis is given to the preparation of natural products or bioactive compounds containing the indole unit.

Syntheses of Macrocyclic Bis(bibenzyl) Compounds Derived from Perrottetin E

Macrocyclic bis(bibenzyl) compounds are natural products from liverworts and are of growing interest due to recent reports on new isolated compounds and on their remarkable biological activities.

Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis

The systematic modification of natural products through diverted total synthesis is a powerful concept for the systematic modification of natural products with the aim of studying mechanistic aspects of their biological activity. This concept offers far?

Concise Total Synthesis of Sintokamides A, B, and E by a Unified, Protecting‐Group‐Free Strategy

One for all: A group of polychlorinated marine peptides known as sintokamides show intriguing activity against hormone?refractory prostate cancer cells. Three members of the group have now been synthesized by a general strategy enabled by a ruthenium?

Enantio‐ and Diastereocontrolled Total Synthesis of (+)‐Strictifolione

A concise and practical enantioselective synthesis of (+)?strictifolione has been achieved in high diastereomeric excess using Jacobsen's hydrolytic kinetic resolution, proline?catalyzed sequential ??aminoxylation and Horner?Wadsworth?Emmons olefination of aldehyde and cross olefin/ring?

Total Syntheses of the Thiopeptides Amythiamicin C and D

The thiopeptides amythiamicin C and D were synthesized by employing amide bond formation, a Stille cross?coupling reaction, and two Negishi cross?coupling reactions as key transformations. The central 2,3,6?trisubstituted pyridine ring of the target compounds was introduced as a 2,6?