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Total Synthesis of Nominal Banyaside B: Structural Revision of the Glycosylation Site

The total synthesis of the tripeptide nominal banyaside?B relies on nonstandard peptide?bond?forming reactions. A key outcome of these synthetic studies is the proposal of a revised structure for natural banyaside?

出版机构:WILEY‐VCH Verlag

刊物名称:Angewandte Chemie International Edition

出版时间:2010

ISSN:1433-7851

数据源:报刊文摘

Total Synthesis of Tryprostatins A and B

A reasonable approach to the radical: The establishment of reliable conditions for the radical?mediated construction of indoles enabled the highly efficient synthesis of tryprostatins?A and B. Use of the radical initiator 2,2??azobis(4?methoxy?2,4?

出版机构:WILEY‐VCH Verlag

刊物名称:Angewandte Chemie International Edition

出版时间:2010

ISSN:1433-7851

数据源:报刊文摘

Salinosporamide Natural Products: Potent 20 S Proteasome Inhibitors as Promising Cancer Chemotherapeutics

Proteasome inhibitors are rapidly evolving as potent treatment options in cancer therapy. One of the most promising drug candidates of this type is salinosporamide?A from the bacterium Salinispora tropica. This marine natural product possesses a complex, densely functionalized ??lactam???

出版机构:WILEY‐VCH Verlag

刊物名称:Angewandte Chemie International Edition

出版时间:2010

ISSN:1433-7851

数据源:报刊文摘

Synthesis of Indole Derivatives with Biological Activity by Reactions Between Unsaturated Hydrocarbons and N-Aromatic Precursors

The present review is devoted to illustrate the state of the art of the syntheses of indoles, focusing particularly on the most recent developments of new synthetic approaches. Emphasis is given to the preparation of natural products or bioactive compounds containing the indole unit.

出版机构:Bentham Science Publishers

刊物名称:Current Organic Chemistry

出版时间:2010

ISSN:1385-2728

数据源:报刊文摘

Syntheses of Macrocyclic Bis(bibenzyl) Compounds Derived from Perrottetin E

Macrocyclic bis(bibenzyl) compounds are natural products from liverworts and are of growing interest due to recent reports on new isolated compounds and on their remarkable biological activities.

出版机构:WILEY‐VCH Verlag

刊物名称:European Journal of Organic Chemistry

出版时间:2010

ISSN:1434-193X

数据源:报刊文摘

Probing the Biology of Natural Products: Molecular Editing by Diverted Total Synthesis

The systematic modification of natural products through diverted total synthesis is a powerful concept for the systematic modification of natural products with the aim of studying mechanistic aspects of their biological activity. This concept offers far?

出版机构:WILEY‐VCH Verlag

刊物名称:Angewandte Chemie International Edition

出版时间:2010

ISSN:1433-7851

数据源:报刊文摘

Concise Total Synthesis of Sintokamides A, B, and E by a Unified, Protecting‐Group‐Free Strategy

One for all: A group of polychlorinated marine peptides known as sintokamides show intriguing activity against hormone?refractory prostate cancer cells. Three members of the group have now been synthesized by a general strategy enabled by a ruthenium?

出版机构:WILEY‐VCH Verlag

刊物名称:Angewandte Chemie International Edition

出版时间:2010

ISSN:1433-7851

数据源:报刊文摘

Enantio‐ and Diastereocontrolled Total Synthesis of (+)‐Strictifolione

A concise and practical enantioselective synthesis of (+)?strictifolione has been achieved in high diastereomeric excess using Jacobsen's hydrolytic kinetic resolution, proline?catalyzed sequential ??aminoxylation and Horner?Wadsworth?Emmons olefination of aldehyde and cross olefin/ring?

出版机构:WILEY‐VCH Verlag

刊物名称:European Journal of Organic Chemistry

出版时间:2010

ISSN:1434-193X

数据源:报刊文摘

Total Syntheses of the Thiopeptides Amythiamicin C and D

The thiopeptides amythiamicin C and D were synthesized by employing amide bond formation, a Stille cross?coupling reaction, and two Negishi cross?coupling reactions as key transformations. The central 2,3,6?trisubstituted pyridine ring of the target compounds was introduced as a 2,6?

出版机构:WILEY‐VCH Verlag

刊物名称:Chemistry - A European Journal

出版时间:2010

ISSN:0947-6539

数据源:报刊文摘