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The kinetically controlled synthesis of cephalexin in aqueous two-phase systems was studied, using immobilized penicillin acylase, 7-amino 3-desacetoxycephalosporanic acid as nucleophile and phenylglycine methyl ester as acyl donor. 出版机构：Elsevier Science 刊物名称：Process Biochemistry 出版时间：2010 ISSN：1359-5113 数据源：报刊文摘
The oxazolidinones are an important class of synthetic bacterial protein synthesis inhibitors with activity against Gram-positive and some fastidious Gram-negative bacteria. 出版机构：Expert Reviews Ltd 刊物名称：Expert Rev. Clin.Immunol. 出版时间：2010 ISSN：1478-7210 数据源：报刊文摘
The thiopeptides amythiamicin C and D were synthesized by employing amide bond formation, a Stille cross?coupling reaction, and two Negishi cross?coupling reactions as key transformations. The central 2,3,6?trisubstituted pyridine ring of the target compounds was introduced as a 2,6?
出版机构：WILEY‐VCH Verlag 刊物名称：Chemistry - A European Journal 出版时间：2010 ISSN：0947-6539 数据源：报刊文摘
Triclosan (TCS), an antimicrobial agent that inhibits bacterial fatty acid synthesis by blocking the active site of enoyl-ACP reductase (FabI), is a water-insoluble agent that limits its therapeutic candidacy. 出版机构：Elsevier Science 刊物名称：European Journal of Pharmaceutical Sciences 出版时间：2011 ISSN：0928-0987 数据源：报刊文摘
Macrolides are produced by various Streptomyces strains and make up a large group of compounds among antibiotics used against various infectious diseases. 出版机构：Bentham Science Publishers 刊物名称：Current Organic Chemistry 出版时间：2011 ISSN：1385-2728 数据源：报刊文摘
Notably, these structures proved that the ribosome is a ribozyme whose active site, namely where the peptide bonds are being formed, is situated within a universal symmetrical region that is embedded in the otherwise asymmetric ribosome structure. 出版机构：WILEY‐VCH Verlag 刊物名称：Angewandte Chemie International Edition 出版时间：2010 ISSN：1433-7851 数据源：报刊文摘
No Abstract 出版机构：WILEY‐VCH Verlag 刊物名称：Angewandte Chemie International Edition 出版时间：2010 ISSN：1433-7851 数据源：报刊文摘
A complex structure: The 2009 Nobel Prize was awarded for investigations into the structure and function of the ribosome, the protein factory of the cell. 出版机构：WILEY‐VCH Verlag 刊物名称：Angewandte Chemie International Edition 出版时间：2010 ISSN：1433-7851 数据源：报刊文摘
The last two decades have witnessed an unsurpassed effort aimed at reconstructing the history of life from the genetic information contained in extant organisms. 出版机构：Elsevier Science 刊物名称：Molecular Phylogenetics and Evolution 出版时间：2005 ISSN：1055-7903 数据源：报刊文摘
Semi-synthetic ?-lactamic antibiotics are the most used anti-bacteria agents, produced in hundreds tons/year scale. It may be assumed that this situation will even increase during the next years, with new ?-lactamic antibiotics under development. 出版机构：Bentham Science Publishers 刊物名称：Current Medicinal Chemistry 出版时间：2010 ISSN：0929-8673 数据源：报刊文摘
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