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Identification of Ligands for the Tau Exon 10 Splicing Regulatory Element RNA by Using Dynamic Combinatorial Chemistry

We describe the use of dynamic combinatorial chemistry (DCC) to identify ligands for the stem?loop structure located at the exon?10?5??intron junction of Tau pre?

出版机构:WILEY‐VCH Verlag

刊物名称:Chemistry - A European Journal

出版时间:2011

ISSN:0947-6539

数据源:报刊文摘

Microwave-Assisted Fluorous Multicomponent Reactions - A Combinatorial Chemistry Approach for Green Organic Synthesis

The development of combinatorial chemistry has significantly improved the efficiency of compound library synthesis for highthroughput screening. This technology could also be used to address the green chemistry concerns in organic synthesis.

出版机构:Bentham Science Publishers

刊物名称:Current Organic Synthesis

出版时间:2011

ISSN:1570-1794

数据源:报刊文摘

A Parallel Screen for the Discovery of Novel DNA Base Pairs

Speed dating: A combinatorial assay was developed for screening a library of aromatic heterocyclic amines for their propensity to act as a complementary base Z in a DNA duplex. This assay may prove useful in speeding up the process of base?

出版机构:WILEY‐VCH Verlag

刊物名称:Angewandte Chemie International Edition

出版时间:2011

ISSN:1433-7851

数据源:报刊文摘

Application of Parallel Synthesis and High Throughput Characterization in Photocatalyst Discovery

The last decade has seen significant progresses in the application of combinatorial approaches and high throughput screening in photocatalyst discovery.

出版机构:Bentham Science Publishers

刊物名称:Combinatorial Chemistry & High Throughput Screening

出版时间:2011

ISSN:1386-2073

数据源:报刊文摘

Solid‐Phase Synthesis of a Combinatorial Methylated (±)‐Epigallocatechin Gallate Library and the Growth‐Inhibitory Effects of these Compounds on Melanoma B16 Cells

We report on the solid?phase synthesis of a combinatorial methylated (?)?epigallocatechin gallate (EGCG) library and its biological evaluation. Epigallocatechin gallate (EGCG) and its methylated derivatives, which are members of the catechin family, exhibit various anti?cancer effects.

出版机构:WILEY‐VCH Verlag

刊物名称:Chemistry - An Asian Journal

出版时间:2010

ISSN:1861-4728

数据源:报刊文摘

Catalytic Asymmetric exo′‐Selective [3+2] Cycloaddition of Iminoesters with Nitroalkenes

Under control: A chiral imidazoline?aminophenol/Ni(OAc)2 complex promotes the first catalytic asymmetric exo??selective [3+2] cycloaddition of iminoesters and nitroalkenes.

出版机构:WILEY‐VCH Verlag

刊物名称:Angewandte Chemie International Edition

出版时间:2010

ISSN:1433-7851

数据源:报刊文摘

Chemistry on Nucleic Acid Templates


出版机构:WILEY‐VCH Verlag

刊物名称:Chemistry & Biodiversity

出版时间:2010

ISSN:1612-1872

数据源:报刊文摘

On resin amino acid side chain attachment strategy for the head to tail synthesis of new glutamine containing gramicidin-S analogs and their antimicrobial activity

The alarming increase in infections caused by multiple drug resistant bacteria including methicillin-resistant Staphylococcus aureus has prompted a desperate search for new antimicrobials.

出版机构:Elsevier Science

刊物名称:Bioorganic & Medicinal Chemistry Letters

出版时间:2010

ISSN:0960-894X

数据源:报刊文摘

Macrocycle or Cage? The Presence or Absence of Ca2+ Template Ions Controls the Equilibrium in an Oligoimine Dynamic Combinatorial Library

A dynamic combinatorial library (DCL) was formed by mixing the triamine 1 and the diamine 3 with the pyridine?2,6?dicarbaldehyde 2 (R = OMe).

出版机构:WILEY‐VCH Verlag

刊物名称:European Journal of Organic Chemistry

出版时间:2011

ISSN:1434-193X

数据源:报刊文摘

Structurally homogeneous and heterogeneous synthetic combinatorial libraries

SummaryWe have designed and synthesized structurally homogeneous and heterogeneous nonpeptide libraries. Structurally homogeneous libraries are characterized by the presence of one common structural unit, a scaffold, in all library compounds (e.g.

出版机构:Springer Netherlands

刊物名称:Molecular Diversity

出版时间:1996

ISSN:1381-1991

数据源:报刊文摘