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I. Photoaffinity probes provide a general method to prepare synthetic peptide-conjugates

AbstractA general synthetic strategy is described for the preparation of peptide-conjugates where the peptides contain the NH2 terminal, COOH terminal, or internal regions of the protein sequence. Glycoprotein D of herpes simplex virus type 1 is used as a representative protein.

出版机构:Kluwer Academic/Plenum Publishers

刊物名称:Journal of Protein Chemistry

出版时间:1984

ISSN:0277-8033

数据源:报刊文摘

Hot or not—the influence of elevated temperature and microwave irradiation on the solid phase synthesis of an affibody

Despite the advances of solid phase peptide synthesis (SPPS) the synthesis of long peptides is still challenging. Microwave irradiation and conventional heating are considered to improve the efficiency of SPPS.

出版机构:Elsevier Science

刊物名称:Tetrahedron Letters

出版时间:2010

ISSN:0040-4039

数据源:报刊文摘

Concise Total Synthesis of Sintokamides A, B, and E by a Unified, Protecting‐Group‐Free Strategy

One for all: A group of polychlorinated marine peptides known as sintokamides show intriguing activity against hormone?refractory prostate cancer cells. Three members of the group have now been synthesized by a general strategy enabled by a ruthenium?

出版机构:WILEY‐VCH Verlag

刊物名称:Angewandte Chemie International Edition

出版时间:2010

ISSN:1433-7851

数据源:报刊文摘

Cell Uptake and Trafficking Behavior of Non‐covalent, Coiled‐coil Based Polymer–Drug Conjugates

This paper reports on the cell uptake and trafficking properties of a series of non?covalent polymer?drug conjugates. These nanomedicines are composed of a poly(N?(2?hydroxypropyl)methacrylamide) backbone functionalized with multiple copies of a drug.

出版机构:WILEY‐VCH Verlag

刊物名称:Macromolecular Rapid Communications

出版时间:2011

ISSN:1022-1336

数据源:报刊文摘

Palmitoylated SDF1 α Shows Increased Resistance against Proteolytic Degradation in Liver Homogenates

The chemokine stromal cell?derived factor?1?? (SDF1??) is strongly involved in organogenesis, as well as inflammation and tissue repair, and acts by attracting different kinds of stem and progenitor cells.

出版机构:WILEY‐VCH Verlag

刊物名称:ChemMedChem

出版时间:2011

ISSN:1860-7179

数据源:报刊文摘

Protein Synthesis Assisted by Native Chemical Ligation at Leucine

No Abstract

出版机构:WILEY‐VCH Verlag

刊物名称:ChemBioChem

出版时间:2010

ISSN:1439-4227

数据源:报刊文摘

Chiral Chalcogen Peptides as Ligands for the Catalytic Enantioselective Aryl Transfer Reaction to Aldehydes

new series of chiral chalcogen peptides were synthesized from inexpensive and commercially available starting materials. The synthesized compounds were tested as catalysts in the enantioselective arylation of aldehydes by using arylboronic acids as the aryl source.

出版机构:WILEY‐VCH Verlag

刊物名称:European Journal of Organic Chemistry

出版时间:2010

ISSN:1434-193X

数据源:报刊文摘

A Novel Family of Onium Salts Based Upon Isonitroso Meldrum's Acid Proves Useful as Peptide Coupling Reagents

Thus, these novel onium salts were often more effective in the acylation of poor nucleophiles and in the control of optical purity than related Oxyma- and benzotriazole-based reagents.

出版机构:WILEY‐VCH Verlag

刊物名称:European Journal of Organic Chemistry

出版时间:2010

ISSN:1434-193X

数据源:报刊文摘