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Chemoenzymatic synthesis and cannabinoid activity of a new diazabicyclic amide of phenylacetylricinoleic acid

The synthesis of a new cannabinoid receptor (CB1R) agonist, derived from ricinoleic acid and a chiral diazabicycle is reported.Endocannabinoids (eCBs) are endogenous neuromodulators of synaptic transmission. Their dysfunction may cause debilitating disorders of diverse clinical manifestation.

出版机构:Elsevier Science

刊物名称:Bioorganic & Medicinal Chemistry Letters

出版时间:2010

ISSN:0960-894X

数据源:报刊文摘

Thermoregulation, pacing and fluid balance during mass participation distance running in a warm and humid environment

Deep body temperature (T c), pacing strategy and fluid balance were investigated during a 21-km road race in a warm and humid environment. Thirty-one males (age 25.3���3.

出版机构:Springer Verlag

刊物名称:European Journal of Applied Physiology

出版时间:2010

ISSN:1439-6319

数据源:报刊文摘

Aural Canal, Esophageal, and Rectal Temperatures During Exertional Heat Stress and the Subsequent Recovery Period


Context:
The measurement of body temperature
is crucial for the initial diagnosis of exertional heat injury and for
monitoring purposes during a subsequent treatment strategy.

出版机构:National Athletic Trainers' Association

刊物名称:Journal of Athletic Training

出版时间:2010

ISSN:1062-6050

数据源:报刊文摘

Influence of Hydration on Physiological Function and Performance During Trail Running in the Heat

Context:
Authors of most field studies have not observed decrements in physiologic function and performance with increases in dehydration, although authors of well-controlled laboratory studies have consistently reported this relationship.

出版机构:National Athletic Trainers' Association

刊物名称:Journal of Athletic Training

出版时间:2010

ISSN:1062-6050

数据源:报刊文摘

Postexercise Cooling Rates in 2 Cooling Jackets


Context:
Cooling jackets are a common method
for removing stored heat accumulated during exercise. To date, the efficiency
and practicality of different types of cooling jackets have received minimal
investigation.

出版机构:National Athletic Trainers' Association

刊物名称:Journal of Athletic Training

出版时间:2010

ISSN:1062-6050

数据源:报刊文摘

Gender markedly modulates behavioral thermoregulation in a non-human primate species, the mouse lemur (Microcebus murinus)

ge and gender are known to significantly modulate thermoregulatory capacities in mammals, suggesting strong impacts on behavioral adjustments, which are used to minimize the energy costs of thermoregulation.

出版机构:Elsevier Science

刊物名称:Physiology & Behavior

出版时间:2010

ISSN:0031-9384

数据源:报刊文摘

The Influence of Age on Thermosensitivity During Cold Water Immersion

This investigation evaluated the influence of older age (OLD) vs younger age (YNG) on thermosensitivity and metabolic heat production (HP) during cold water immersion (20?C) in 15 YNG (22.7?2.7 years) vs 7 OLD (41.7?2.7 years) individuals.

出版机构:Elsevier Science

刊物名称:Wilderness & Environmental Medicine

出版时间:2002

ISSN:1080-6032

数据源:报刊文摘

Monte Carlo simulations of individual variability and their effects on simulated heat stress using thermoregulatory modeling

This paper addresses a variable-dependence (VD) MC method developed based on a previous attempt (VI-MC method) (J. Therm. Biol. 29 (2004), 515) to be incorporated in a thermoregulatory model.

出版机构:Elsevier Science

刊物名称:Journal of Thermal Biology

出版时间:2010

ISSN:0306-4565

数据源:报刊文摘

Behavioral and autonomic responses to intermittent social stress: differential protection by clonidine and metoprolol

Over the course of the initial 4-weekly threat encounters the acute tachycardia but not the hyperthermic stress responses decreased in magnitude. Following the first three threat encounters core temperature (Tc) was significantly elevated for at least 3 h.

出版机构:Springer Verlag

刊物名称:Psychopharmacology

出版时间:1994

ISSN:0033-3158

数据源:报刊文摘

Characteristics of the control of human thermoregulatory behavior

The aim of this study was to characterize several of the thermal input(s) that influence thermo-behavior in humans. Eight male subjects completed two trials in which they were free to initiate an exit from a hot chamber (45?C) to a cold chamber (10?C; H?C) or from a cold chamber to a hot chamber (C?

出版机构:Elsevier Science

刊物名称:Physiology & Behavior

出版时间:2009

ISSN:0031-9384

数据源:报刊文摘