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Bcl-2 family proteins have long been implicated in the pathology of chronic lymphocytic leukaemia (CLL). Indeed, a number of these proteins have been shown to have prognostic importance in this disease. 出版机构:Elsevier Science 刊物名称:Leukemia Research 出版时间:2010 ISSN:0145-2126 数据源:报刊文摘
The present study tests the hypothesis that hyperoxia results in increased tyrosine phosphorylation of apoptotic proteins Bcl-2, Bcl-xl, Bax & Bad in the mitochondrial fraction of the cerebral cortex of newborn piglets.
出版机构:Springer US 刊物名称:Neurochemical Research 出版时间:2010 ISSN:0364-3190 数据源:报刊文摘
Epidemiologic studies have revealed a higher incidence of cataracts in estrogen-deprived postmenopausal women, although the pathogenic mechanism has not yet been elucidated. Apoptosis of lens epithelial cells has been associated with cataractogenesis.
出版机构:Springer Netherlands 刊物名称:International Ophthalmology 出版时间:2010 ISSN:0165-5701 数据源:报刊文摘
Ischemia was produced in rats by ligature of the left anterior descending coronary artery for 30min. At the end of the 2-h reperfusion, western blot analysis of the inflammatory and apoptotic markers tumor necrosis factor-? (TNF-? 出版机构:Elsevier Science 刊物名称:European Journal of Pharmacology 出版时间:2010 ISSN:0014-2999 数据源:报刊文摘
Our previous studies demonstrated that KG-135, a quality-controlled red ginseng-specific formulation containing approximately equal amounts of three major ginsenosides (Rk1, Rg3 and Rg5), down-regulated G1 cyclin-dependent kinase in HeLa cells. 出版机构:Elsevier Science 刊物名称:Cancer Letters 出版时间:2010 ISSN:0304-3835 数据源:报刊文摘
Objects Medulloblastoma (MB) is the most malignant primary brain tumor in early childhood that contains cellular and functional heterogeneity.
出版机构:Springer Verlag 刊物名称:Child's Nervous System 出版时间:2010 ISSN:0256-7040 数据源:报刊文摘
The cytomegaloviruses (CMVs) are a family of species-specific viruses that have evolved sophisticated methods to interfere with the host's ability to generate innate and adaptive immune responses.
出版机构:Blackwell Publishing Ltd 刊物名称:Tissue Antigens 出版时间:2010 ISSN:0001-2815 数据源:报刊文摘
Tumor cells are protected against intercellular reactive oxygen species (ROS)-mediated apoptosis signaling mediated by the HOCl and/or the nitric oxide (NO)/peroxynitrite signaling pathway.
出版机构:Walter de Gruyter 刊物名称:Biological Chemistry 出版时间:2010 ISSN:1437-4315 数据源:报刊文摘
Mitochondria increasingly attract attention as control points within the mechanisms of neuronal death. Mitochondria play a central role in swinging the balance in favor of either survival or death of brain tissue.
出版机构:Walter de Gruyter 刊物名称:Biological Chemistry 出版时间:2010 ISSN:1437-4315 数据源:报刊文摘
The preferred amino acids in the proteolytic sites have been considered to be similar between caspase-1 and caspase-9, which do not support their differential functions in inflammatory pyroptosis and apoptosis. We attempted to solve this problem. 出版机构:Elsevier Science 刊物名称:Atherosclerosis 出版时间:2010 ISSN:0021-9150 数据源:报刊文摘
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