The role of Bcl-2 family proteins in chronic lymphocytic leukaemia

Bcl-2 family proteins have long been implicated in the pathology of chronic lymphocytic leukaemia (CLL). Indeed, a number of these proteins have been shown to have prognostic importance in this disease.

Tyrosine Phosphorylation of Apoptotic Proteins During Hyperoxia in Mitochondria of the Cerebral Cortex of Newborn Piglets

The present study tests the hypothesis that hyperoxia results in increased tyrosine phosphorylation of apoptotic proteins Bcl-2, Bcl-xl, Bax & Bad in the mitochondrial fraction of the cerebral cortex of newborn piglets.

出版机构：Springer US

刊物名称：Neurochemical Research

出版时间：2010

ISSN：0364-3190

数据源：报刊文摘

Effect of estrogen replacement therapy on lens epithelial cell apoptosis in an experimental rat model

Epidemiologic studies have revealed a higher incidence of cataracts in estrogen-deprived postmenopausal women, although the pathogenic mechanism has not yet been elucidated. Apoptosis of lens epithelial cells has been associated with cataractogenesis.

出版机构：Springer Netherlands

刊物名称：International Ophthalmology

出版时间：2010

ISSN：0165-5701

数据源：报刊文摘

Melanocortins counteract inflammatory and apoptotic responses to prolonged myocardial ischemia/reperfusion through a vagus nerve-mediated mechanism

Ischemia was produced in rats by ligature of the left anterior descending coronary artery for 30min. At the end of the 2-h reperfusion, western blot analysis of the inflammatory and apoptotic markers tumor necrosis factor-? (TNF-?

Potentiation of etoposide-induced apoptosis in HeLa cells by co-treatment with KG-135, a quality-controlled standardized ginsenoside formulation

Our previous studies demonstrated that KG-135, a quality-controlled red ginseng-specific formulation containing approximately equal amounts of three major ginsenosides (Rk1, Rg3 and Rg5), down-regulated G1 cyclin-dependent kinase in HeLa cells.

Medulloblastoma-derived tumor stem-like cells acquired resistance to TRAIL-induced apoptosis and radiosensitivity

Objects Medulloblastoma (MB) is the most malignant primary brain tumor in early childhood that contains cellular and functional heterogeneity.

出版机构：Springer Verlag

刊物名称：Child's Nervous System

出版时间：2010

ISSN：0256-7040

数据源：报刊文摘

Suicide watch: how cytomegalovirus interferes with the cell-death pathways of infected cells

The cytomegaloviruses (CMVs) are a family of species-specific viruses that have evolved sophisticated methods to interfere with the host's ability to generate innate and adaptive immune responses.

Multiple protective functions of catalase against intercellular apoptosis-inducing ROS signaling of human tumor cells

Tumor cells are protected against intercellular reactive oxygen species (ROS)-mediated apoptosis signaling mediated by the HOCl and/or the nitric oxide (NO)/peroxynitrite signaling pathway.

The mitochondria permeability transition pore complex in the brain with interacting proteins – promising targets for protection in neurodegenerative diseases

Mitochondria increasingly attract attention as control points within the mechanisms of neuronal death. Mitochondria play a central role in swinging the balance in favor of either survival or death of brain tissue.

Caspase-1 recognizes extended cleavage sites in its natural substrates

The preferred amino acids in the proteolytic sites have been considered to be similar between caspase-1 and caspase-9, which do not support their differential functions in inflammatory pyroptosis and apoptosis. We attempted to solve this problem.