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In vivo hepatic endoplasmic reticulum stress in patients with chronic hepatitis CNo conflicts of interest were declared.

In hepatocytes, the accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress and the unfolded protein response (UPR), mediated by the ER-resident stress sensors ATF-6, IRE1, and PERK. UPR-responsive genes are involved in the fate of ER-stressed cells.

出版机构:John Wiley & Sons, Ltd.

刊物名称:The Journal of Pathology

出版时间:2010

ISSN:0022-3417

数据源:报刊文摘

Melanocortins counteract inflammatory and apoptotic responses to prolonged myocardial ischemia/reperfusion through a vagus nerve-mediated mechanism

Ischemia was produced in rats by ligature of the left anterior descending coronary artery for 30min. At the end of the 2-h reperfusion, western blot analysis of the inflammatory and apoptotic markers tumor necrosis factor-? (TNF-?

出版机构:Elsevier Science

刊物名称:European Journal of Pharmacology

出版时间:2010

ISSN:0014-2999

数据源:报刊文摘

High-dose antithrombin III prevents heat stroke by attenuating systemic inflammation in rats

Objective Systemic inflammatory mediators, including the high mobility group box 1 (HMGB1) protein, play important roles in the development of various inflammatory conditions.

出版机构:SP Birkhäuser Verlag Basel

刊物名称:Inflammation Research

出版时间:2010

ISSN:1023-3830

数据源:报刊文摘

Increased levels of resistin in rotating shift workers: A potential mediator of cardiovascular risk associated with circadian misalignment

Shift work schedule has been associated with several health problems, including deleterious effects on the cardiovascular system.

出版机构:Elsevier Science

刊物名称:Atherosclerosis

出版时间:2010

ISSN:0021-9150

数据源:报刊文摘

Relationship between Mediterranean Diet Score and atherothrombotic risk: Findings from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994

Mediterranean diet has been promoted as the preferred dietary model for cardiovascular disease prevention in the United States.

出版机构:Elsevier Science

刊物名称:Atherosclerosis

出版时间:2010

ISSN:0021-9150

数据源:报刊文摘

A toxicological evaluation of inhaled solid lipid nanoparticles used as a potential drug delivery system for the lung

Inhalation is a non-invasive approach for both local and systemic drug delivery. This study aimed to define the therapeutic window for solid lipid nanoparticles (SLNs) as a drug delivery system by inhalation from a toxicological point of view.

出版机构:Elsevier Science

刊物名称:European Journal of Pharmaceutics and Biopharmaceutics

出版时间:2010

ISSN:0939-6411

数据源:报刊文摘

Evaluation of translocator protein quantification as a tool for characterising macrophage burden in human carotid atherosclerosis

Macrophage presence within atherosclerotic plaque is a feature of instability and a risk factor for plaque rupture and clinical events. Activated macrophages express high levels of the translocator protein/peripheral benzodiazepine receptor (TSPO/PBR).

出版机构:Elsevier Science

刊物名称:Atherosclerosis

出版时间:2010

ISSN:0021-9150

数据源:报刊文摘

Caspase-1 recognizes extended cleavage sites in its natural substrates

The preferred amino acids in the proteolytic sites have been considered to be similar between caspase-1 and caspase-9, which do not support their differential functions in inflammatory pyroptosis and apoptosis. We attempted to solve this problem.

出版机构:Elsevier Science

刊物名称:Atherosclerosis

出版时间:2010

ISSN:0021-9150

数据源:报刊文摘

Serine proteases of the human immune system in health and disease

Serine proteases form a large family of protein-cleaving enzymes that play an essential role in processes like blood coagulation, apoptosis and inflammation.

出版机构:Elsevier Science

刊物名称:Molecular Immunology

出版时间:2010

ISSN:0161-5890

数据源:报刊文摘