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Inhibition of the transcriptional function of p53 by EWS–Fli1 chimeric protein in Ewing Family Tumors

The chromosomal translocation t(11;22)(q24;q12) generates the EWS?Fli1 fusion gene, which contributes to the development of Ewing Family Tumors (EFTs). Although p53 mutations are found only in 5?20% of EFTs, the p53 pathway is thought to be abrogated in EFTs. The role of EWS?

出版机构:Elsevier Science

刊物名称:Cancer Letters

出版时间:2010

ISSN:0304-3835

数据源:报刊文摘

Potentiation of etoposide-induced apoptosis in HeLa cells by co-treatment with KG-135, a quality-controlled standardized ginsenoside formulation

Our previous studies demonstrated that KG-135, a quality-controlled red ginseng-specific formulation containing approximately equal amounts of three major ginsenosides (Rk1, Rg3 and Rg5), down-regulated G1 cyclin-dependent kinase in HeLa cells.

出版机构:Elsevier Science

刊物名称:Cancer Letters

出版时间:2010

ISSN:0304-3835

数据源:报刊文摘

A label-free electrochemical test for DNA-binding activities of tumor suppressor protein p53 using immunoprecipitation at magnetic beads

The technique relies on capture of the p53?DNA complexes at MB via anti-p53 antibodies, followed by salt-induced dissociation of linear DNA from the complex and its voltammetric detection.

出版机构:Elsevier Science

刊物名称:Analytica Chimica Acta

出版时间:2010

ISSN:0003-2670

数据源:报刊文摘

The ubiquitin–proteasome system is inhibited by p53 protein expression in human ovarian cancer cells

The ubiquitin?proteasome system (UPS) and autophagy provide major cellular pathways for protein degradation. Since the p53 pathway controls autophagy, we investigated whether p53 regulates UPS in ovarian tumour cell lines.

出版机构:Elsevier Science

刊物名称:Cancer Letters

出版时间:2010

ISSN:0304-3835

数据源:报刊文摘

Fibroblast growth factor-2 transiently activates the p53 oncosuppressor protein in human primary vascular smooth muscle cells: Implications for atherogenesis

The development of atherosclerotic lesions associates with the proliferation of vascular smooth muscle cells (VSMC), and their migration from arterial tunica media to the intima.

出版机构:Elsevier Science

刊物名称:Atherosclerosis

出版时间:2010

ISSN:0021-9150

数据源:报刊文摘

Induction of the small heat shock protein αB-crystallin by genotoxic stress is mediated by p53 and p73

The small heat shock protein ?B-crystallin is a molecular chaperone that is induced by stress and protects cells by inhibiting protein aggregation and apoptosis. To identify novel transcriptional regulators of the ?B-crystallin gene, we examined the ?

出版机构:Springer US

刊物名称:Breast Cancer Research and Treatment

出版时间:2010

ISSN:0167-6806

数据源:报刊文摘

Wild type but not mutant APP is involved in protective adaptive responses against oxidants

We found that the two clones differed, especially, in terms of redox profile. HEK-APPmut cells were characterized by higher levels of oxidative markers in comparison with HEK-APPwt.

出版机构:Springer Vienna

刊物名称:Amino Acids

出版时间:2010

ISSN:0939-4451

数据源:报刊文摘

ROS leads to MnSOD upregulation through ERK2 translocation and p53 activation in selenite-induced apoptosis of NB4 cells

Following our previous finding that sodium selenite induces apoptosis in human leukemia NB4 cells, we now show that the expression of the critical antioxidant enzyme manganese superoxide dismutase (MnSOD) is remarkably elevated during this process.

出版机构:Elsevier Science

刊物名称:FEBS Letters

出版时间:2010

ISSN:0014-5793

数据源:报刊文摘

Structural characterization of p53 isoforms due to the polymorphism at codon 72 by mass spectrometry and circular dichroism

ommon polymorphism at codon 72 of human TP53 gene determines a proline to arginine aminoacidic substitution within the proline-rich domain of p53 protein.

出版机构:Elsevier Science

刊物名称:Journal of Pharmaceutical and Biomedical Analysis

出版时间:2010

ISSN:0731-7085

数据源:报刊文摘

Switching p53-dependent growth arrest to apoptosis via the inhibition of DNA damage-activated kinases

Cisplatin and doxorubicin are widely used anticancer drugs that cause DNA damage, which activates the ATM-Chk2-p53 pathway in cancer cells. This activation leads to cell cycle block or apoptosis, depending on the nature of the DNA damage.

出版机构:SP Versita

刊物名称:Cellular & Molecular Biology Letters

出版时间:2010

ISSN:1425-8153

数据源:报刊文摘