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Putative γ‐aminobutyric acid neurons in the ventral tegmental area have a similar pattern of plasticity as dopamine neurons during appetitive and aversive learning

Given the modulatory nature of dopamine neurotransmission, that dopamine release is activated by both aversive and appetitive stimuli, and that dopamine receptors are often localized extrasynaptically, a role for dopamine in transmitting precise error signals has been questioned.

出版机构:Blackwell Publishing Ltd

刊物名称:European Journal of Neuroscience

出版时间:2010

ISSN:0953-816X

数据源:报刊文摘

Gene expression profiling in brain regions of a rat model displaying schizophrenia-related features

To understand the molecular basis underlying this phenotype, we here performed mRNA expression profiling in various APO-SUS and APO-UNSUS rat brain regions.

出版机构:Elsevier Science

刊物名称:Behavioural Brain Research

出版时间:2010

ISSN:0166-4328

数据源:报刊文摘

Levels of phosphodiesterase 4A and 4B are altered by chronic treatment with psychotropic medications in rat frontal cortex

Our laboratory has recently demonstrated altered expression of phosphodiesterase (PDE) 4A and 4B in subjects with autism, bipolar disorder, and schizophrenia, suggesting disrupted cAMP signaling in these diagnostic groups.

出版机构:Wiley Subscription Services, Inc., A Wiley Company

刊物名称:Synapse

出版时间:2010

ISSN:0887-4476

数据源:报刊文摘

Changes in the acoustic startle response and prepulse inhibition of acoustic startle in rats after local injection of pertussis toxin into the ventral tegmental area

AbstractThe effect of local injection of pertussis toxin (PTX) into the ventral tegmental area (VTA) on acoustic startle in rats was investigated. The PTX treatment caused only minor effects of its own on the acoustic startle response (ASR) or prepulse inhibition (PPI) of acoustic startle.

出版机构:Springer Verlag

刊物名称:Psychopharmacology

出版时间:1995

ISSN:0033-3158

数据源:报刊文摘

Risperidone (R 64 766), a potent and complete LSD antagonist in drug discrimination by rats

AbstractRisperidone was studied in a 0.16 mg/kg LSD-saline drug discrimination test procedure. At doses varying from 0.0025 to 0.63 mg/kg, no LSD-like agonist effects were observed.

出版机构:Springer Verlag

刊物名称:Psychopharmacology

出版时间:1989

ISSN:0033-3158

数据源:报刊文摘

Examination of drug-induced and isolation-induced disruptions of prepulse inhibition as models to screen antipsychotic drugs

AbstractPrepulse inhibition (PPI) of an acoustic startle response is impaired in schizophrenics. PPI can also be studied in the rat, and is impaired by dopamine (DA) D2/3 receptor agonists such as apomorphine.

出版机构:Springer Verlag

刊物名称:Psychopharmacology

出版时间:1995

ISSN:0033-3158

数据源:报刊文摘

Prepulse inhibition of the acoustic startle response of rats is reduced by 6-hydroxydopamine lesions of the medial prefrontal cortex

AbstractPrepulse inhibition (PPI) of the acoustic startle response (ASR) is impaired by dopamine (DA) overactivity in the nucleus accumbens and anteromedial striatum.

出版机构:Springer Verlag

刊物名称:Psychopharmacology

出版时间:1994

ISSN:0033-3158

数据源:报刊文摘

Effect of antibodies to dopamine-β-monooxygenase on brain catecholamine levels

Without Abstract

出版机构:Springer US

刊物名称:Bulletin of Experimental Biology and Medicine

出版时间:1991

ISSN:0007-4888

数据源:报刊文摘

Abolition of the expression but not the acquisition of latent inhibition by chronic amphetamine in rats

AbstractThe animal amphetamine model of schizophrenia has been based primarily on stereotyped behavior. The present study sought to demonstrate an amphetamine-induced deficit in attentional processes. To this end, the effects of acute and chronic (14 days) 1.

出版机构:Springer Verlag

刊物名称:Psychopharmacology

出版时间:1984

ISSN:0033-3158

数据源:报刊文摘

Effects of antipsychotic drugs on latent inhibition: sensitivity and specificity of an animal behavioral model of clinical drug action

AbstractLatent inhibition (LI) of a conditioned emotional response (CER) has been proposed as a quantitative measure of selective attention. We have assessed the parallels of the pharmacology of LI in rats with the clinical pharmacology of schizophrenia.

出版机构:Springer Verlag

刊物名称:Psychopharmacology

出版时间:1993

ISSN:0033-3158

数据源:报刊文摘