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Reduction of carcinogenicity of N-nitrosomethylurea by indomethacin and failure of resuming effect of prostaglandin E2 (PGE2) against indomethacin

SummaryNonsteroid antiinflammatory drugs such as indomethacin may play an important role in preventing the development of chemically induced experimental carcinomas of various organs including the large bowel in rats and mice.

出版机构:Springer Verlag

刊物名称:Journal of Cancer Research and Clinical Oncology

出版时间:1984

ISSN:0171-5216

数据源:报刊文摘

Discriminative stimulus properties of β-carbolines characterized as agonists and inverse agonists at central benzodiazepine receptors

AbstractThe discriminative stimulus properties of three -carboline derivatives were studied in three groups of rats trained, respectively, to discriminate diazepam (2.

出版机构:Springer Verlag

刊物名称:Psychopharmacology

出版时间:1984

ISSN:0033-3158

数据源:报刊文摘

Dose-response study of urinary bladder carcinogenesis in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine

SummaryA dose-response study was carried out in male F344 rats with a specific urinary bladder carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN), which was administered as a solution in drinking water for up to 112 weeks.

出版机构:Springer Verlag

刊物名称:Journal of Cancer Research and Clinical Oncology

出版时间:1984

ISSN:0171-5216

数据源:报刊文摘

Modification of nigral kainic acid-induced ipsilateral circling behaviour in the rat by neuroleptics and by contralateral caudate ablation

AbstractA study was performed to examine possible changes in excitatory amino acid sensitivity within the pars reticulata of the rat substantia nigra as a result of neuroleptic exposure.

出版机构:Springer Verlag

刊物名称:Psychopharmacology

出版时间:1984

ISSN:0033-3158

数据源:报刊文摘

Self-injection of diazepam in naive rats: Effects of dose, schedule and blockade of different receptors

AbstractThe present series of experiments had two main objectives: The first was to determine the conditions under which self-injection of the benzodiazepine diazepam would be optimal; the second was to identify neurochemical substrates which underlie the maintenance of diazepam selfadministration.

出版机构:Springer Verlag

刊物名称:Psychopharmacology

出版时间:1984

ISSN:0033-3158

数据源:报刊文摘

Differential effects of continuous administration for 1 year of haloperidol or sulpiride on striatal dopamine function in the rat

AbstractAdministration of haloperidol (1.4–1.6 mg/kg/day) for up to 12 months or sulpiride (102–109 mg/kg/day) for between 6 and 12 months increased the frequency of purposeless chewing jaw movements in rats. N,n-propylnorapomorphine (NPA) (0.25–2.

出版机构:Springer Verlag

刊物名称:Psychopharmacology

出版时间:1984

ISSN:0033-3158

数据源:报刊文摘

A new benzothiadiazine derivative, LN 5330: effects on pancreatic hormones

SummaryLN 5330 is a new benzothiadiazine which is a structural analogue of diazoxide. Its effects in vivo were studied on blood glucose levels and insulin, glucagon and somatostatin secretion in normal dogs, and in vitro on glucagon and insulin secretion from the isolated perfused rat pancreas.

出版机构:Springer Verlag

刊物名称:Diabetologia

出版时间:1984

ISSN:0012-186X

数据源:报刊文摘

Volume control during periodic changes of blood volume in the alert rat

SummaryBlood (3.4–13.5% of blood volume) was pumped in and out of the circulation of rats at different rates and period lengths during continuous measurements of blood conductivity (reciprocally related to hematocrit) and arterial pressure.

出版机构:Springer Verlag

刊物名称:Basic Research in Cardiology

出版时间:1984

ISSN:0300-8428

数据源:报刊文摘

Δ1-tetrahydrocannabinol-induced circling behavior in rats: A possible measure of psychotomimetic activity?

AbstractRelatively high dosages of 1-tetrahydrocannabinol (1-THC) markedly suppressed almost all normally occurring behavioral elements in rats as observed in both a small and a large open field. This effect persisted following repeated treatment and testing for 3 consecutive days.

出版机构:Springer Verlag

刊物名称:Psychopharmacology

出版时间:1984

ISSN:0033-3158

数据源:报刊文摘

DNA methylation in maternal, fetal and neonatal rat tissues following perinatal administration of procarbazine

The concentration of the major adduct N7-methylguanine was highest in the maternal liver (224 mol/mol guanine). Fetal and nonhepatic maternal tissues exhibited significantly lower levels, but differed little from each other.

出版机构:Springer Verlag

刊物名称:Journal of Cancer Research and Clinical Oncology

出版时间:1984

ISSN:0171-5216

数据源:报刊文摘