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Combination of Thiazide Diuretics and Angiotensin Receptor Blockers Attenuates Osteoporosis in Hypertensive Rats

eries of clinical studies have shown that thiazide diuretics (TD) might reduce the risk of bone fractures. We also recently demonstrated that angiotensin receptor blockers (ARB) ameliorated ovariectomy (OVX)-induced osteoporosis in a hypertensive rat model.

出版机构:Bentham Science Publishers

刊物名称:Immunology, Endocrine & Metabolic Agents - Medicinal Chemistry (Formerly Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents)

出版时间:2010

ISSN:1871-5222

数据源:报刊文摘

Single high dose treatment with methotrexate causes long-lasting cognitive dysfunction in laboratory rodents

g. within 1month of treatment). Male hooded Wistar rats (N=22) received either a high dose of methotrexate (MTX: 250mg/kg i.p.) or physiological saline.

出版机构:Elsevier Science

刊物名称:Pharmacology Biochemistry & Behavior

出版时间:2010

ISSN:0091-3057

数据源:报刊文摘

Exposure to alcohol during adolescence alters the aversive and locomotor-activating effects of cocaine in adult rats

The present study assessed the effect of adolescent alcohol exposure on the later aversive and locomotor-activating effects of cocaine.? The present study assessed the long-term effects of adolescent alcohol exposure. ?

出版机构:Elsevier Science

刊物名称:Pharmacology Biochemistry & Behavior

出版时间:2010

ISSN:0091-3057

数据源:报刊文摘

Chronic inhibition of farnesyl pyrophosphate synthase improves endothelial function in spontaneously hypertensive rats

Farnesyl pyrophosphate synthase (FPPS, EC 2.5.1.10), an essential enzyme in the mevalonate pathway, catalyzes the synthesis of isoprenoid intermediates.

出版机构:Elsevier Science

刊物名称:Biochemical Pharmacology

出版时间:2010

ISSN:0006-2952

数据源:报刊文摘

HPLC method with fluorescence detection for the quantitative determination of flaxseed lignans

We report a rapid and simple HPLC method with fluorescence detection for the quantification of the major flaxseed lignan, secoisolarisiresinol diglucoside (SDG) and its major metabolites. The method is specific for SDG, secoisolarisiresinol (SECO), enterodiol (ED) and entrolactone (EL) in rat serum.

出版机构:Elsevier Science

刊物名称:Journal of Chromatography B, Analytical Technologies in the Biomedical and

出版时间:2010

ISSN:1570-0232

数据源:报刊文摘

Administration of GABAB receptor positive allosteric modulators inhibit the expression of previously established methamphetamine-induced conditioned place preference

? Methamphetamine place preference is disrupted by GABAB receptor modulators. ? Memory maintenance is disrupted by augmenting endogenous GABA. ? GABAB receptor positive allosteric modulators may treat psychostimulant addiction.

出版机构:Elsevier Science

刊物名称:Behavioural Brain Research

出版时间:2011

ISSN:0166-4328

数据源:报刊文摘

Femtosecond light distribution at skin and liver of rats: analysis for use in optical diagnostics

In this study we investigated the light distribution under femtosecond laser illumination and its correlation with the collected diffuse scattering at the surface of ex?vivo rat skin and liver. The reduced scattering coefficients ? ?

出版机构:WILEY‐VCH Verlag

刊物名称:Laser Physics Letters

出版时间:2010

ISSN:1612-2011

数据源:报刊文摘

Tissue Specific Distribution of Pyrimidine Deoxynucleoside Salvage Enzymes Shed Light on the Mechanism of Mitochondrial DNA Depletion

Deficiency in thymidine kinase 2 (TK2) activity due to genetic alterations caused tissue specific mitochondrial DNA (mtDNA) depletion syndrome with symptoms resembling these of AIDS patients treated with nucleoside analogues. Mechanisms behind this mitochondrial effects is still not well understood.

出版机构:Taylor & Francis

刊物名称:Nucleosides Nucleotides

出版时间:2010

ISSN:1525-7770

数据源:报刊文摘

Formation of bone-like tissue by dental follicle cells co-cultured with dental papilla cells

During tooth root formation, dental follicle cells (DFCs) differentiate into osteoblasts/cementoblasts when they are in contact with pre-existing dentin.

出版机构:Springer Verlag

刊物名称:Cell and Tissue Research

出版时间:2010

ISSN:0302-766X

数据源:报刊文摘

The role of CTGF in the diabetic rat retina and its relationship with VEGF and TGF‐β2, elucidated by treatment with CTGFsiRNA

Acta Ophthalmol. 2010: 88: 652 659

Abstract.

Purpose: The critical association of connective tissue growth factor (CTGF) with diabetic retinopathy (DR) remains to be clarified.

出版机构:Blackwell Publishing Ltd

刊物名称:Acta Ophthalmologica

出版时间:2010

ISSN:1755-375X

数据源:报刊文摘